74974-42-8

Basic information

• Product Name: (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)-hex-3-enoylglycyl-L-phenylalanyl-L-leucine methyl ester
• CAS NO: 74974-42-8
• Molecular Weight: 708.896
• Mol File: 74974-42-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)-hex-3-enoylglycyl-L-phenylalanyl-L-leucine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)-hex-3-enoylglycyl-L-phenylalanyl-L-leucine methyl ester(74974-42-8)
• EPA Substance Registry System: (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)-hex-3-enoylglycyl-L-phenylalanyl-L-leucine methyl ester(74974-42-8)

Safety Data

• Hazardous Substances Data: 74974-42-8(Hazardous Substances Data)

Upstream product

• 2577-90-4 L-phenylalanine methyl ester 
• 74974-38-2 (S)-trans-2-t-butoxycarbonylamino-1-(4-t-butoxyphenyl)-6-trimethylsilylhex-3-en-5-yne 
• 4530-17-0 N-t-butoxycarbonylglycyl-L-phenylalanine 
• 3982-70-5 N-t-butoxycarbonylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 74974-40-6 (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)hex-3-enoic acid 
• 4368-66-5 H-Gly-L-Phe-L-Leu-OMe 

Downstream Products

• 74974-43-9 (S)-trans-5-amino-6-(4-hydroxyphenyl)hex-3-enoylglycyl-L-phenylalanyl-L-leucine 
• 82464-45-7 (R)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)hex-2-enoylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 82464-46-8 (R)-trans-6-amino-6-(4-hydroxyphenyl)hex-2-enoylglycyl-L-phenylalanyl-L-leucine 
• 82464-47-9 (R)-trans-5-t-butoxycarbonylamino-6-(4-butoxyphenyl)hex-2-enoylglycyl-L-phenylalanyl-L-leucine 

Relevant articles and documents

On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue

Methodology for preparing dipeptide analogues in which a carbon -carbon double bond replaces the normal amide bond is described.Thus, the protected tyrosylglycine analogue, (S)-trans-5-t-butyloxycarbonylamino-6-(4-t-butoxyphenyl)hex-3-enoic acid has been synthesised and incorporated into the Leu-enkephalin analogue (3) by condensation with glycylphenylalanyl-leucine.The enkephalin analogue retained biological activity.The significance of this isosteric replacement of the amide group is discussed.