3982-70-5

Basic information

• Product Name: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, methyl ester
• CAS NO: 3982-70-5
• Molecular Formula: C23H35N3O6
• Molecular Weight: 449.547
• Mol File: 3982-70-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, methyl ester(3982-70-5)
• EPA Substance Registry System: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, methyl ester(3982-70-5)

Safety Data

• Hazardous Substances Data: 3982-70-5(Hazardous Substances Data)

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 2577-90-4 L-phenylalanine methyl ester 
• 4530-20-5 BOC-glycine 
• 2666-93-5 L-Leucine methyl ester 
• 4530-17-0 N-t-butoxycarbonylglycyl-L-phenylalanine 
• 4192-12-5 Boc-Phe-OH*DCHA 
• 64152-76-7 Boc-Phe-Leu-OMe 
• 6322-53-8 leucine methyl ester hydrochloride 
• 38155-45-2 H-Phe-Leu-OMe*HCl 
• 89093-60-7 2-(2-tert-Butoxycarbonylamino-acetylamino)-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 147781-99-5 Boc-Gly-DL-Phe(β-OH)-OH 
• 124194-31-6 Boc-Gly-Δ^ZPhe azlactone 
• 42267-16-3 (d,l)-phenylserine ethyl ester hydrochloride 
• 90761-06-1 ^tBOC-Gly-ΔPhe-(S)-Leu-OMe 

Downstream Products

• 74974-43-9 (S)-trans-5-amino-6-(4-hydroxyphenyl)hex-3-enoylglycyl-L-phenylalanyl-L-leucine 
• 74974-42-8 (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)-hex-3-enoylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 75975-40-5 cyclo-Leu⁵-Enkephalin 
• 80727-53-3 Boc-Gly-Phe-Leu-Tyr-Gly-N₂H₃ 
• 77591-04-9 Boc-Gly-Phe-Leu-Tyr-Gly-OMe 
• 80727-50-0 Boc-Gly-Phe-Leu-N₂H₃ 

Relevant articles and documents

SYNTHESIS OF CHIRAL OLIGOPEPTIDES BY MEANS OF CATALYTIC ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES

Asymmetric hydrogenation of Ac-ΔTyr(Ac)-(S)-Ala-Gly-OMe (6), Ac-ΔTyr(Ac)-(R)-Ala-Gly-(S)-Phe-OMe (7), Ac-ΔPhe-NH-CH(R)-CH2-OCH2Ph (10), HCO-ΔPhe-(S)-Leu-OMe (16), X-AA-ΔPhe-AA'-OMe ( 5: X=tBOC, CBZ, CF3CO; AA, AA'= α-amino acid ), and t

On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue

Methodology for preparing dipeptide analogues in which a carbon -carbon double bond replaces the normal amide bond is described.Thus, the protected tyrosylglycine analogue, (S)-trans-5-t-butyloxycarbonylamino-6-(4-t-butoxyphenyl)hex-3-enoic acid has been synthesised and incorporated into the Leu-enkephalin analogue (3) by condensation with glycylphenylalanyl-leucine.The enkephalin analogue retained biological activity.The significance of this isosteric replacement of the amide group is discussed.