7500-39-2

Basic information

• Product Name: 5-Phenyl-2-azepanone
• Synonyms: 5-Phenyl-2-azepanone;5-Phenylazepan-2-one
• CAS NO: 7500-39-2
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.25
• Mol File: 7500-39-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 229 °C
• Appearance: /
• Density: 1.046 g/cm³
• Vapor Pressure: 4.12E-06mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Phenyl-2-azepanone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Phenyl-2-azepanone(7500-39-2)
• EPA Substance Registry System: 5-Phenyl-2-azepanone(7500-39-2)

Safety Data

• Hazardous Substances Data: 7500-39-2(Hazardous Substances Data)

Usage

General Description

5-Phenyl-2-azepanone is a chemical compound with the molecular formula C13H15NO. It belongs to the class of organic compounds known as beta-lactams, which are cyclic amides with a 4-atom ring. 5-Phenyl-2-azepanone is a colorless to yellow liquid with a slightly sweet odor. 5-Phenyl-2-azepanone is commonly used as an intermediate in the manufacture of pharmaceuticals and other organic compounds. It is also used in research and development as a building block for the synthesis of various heterocyclic compounds. This chemical has potential applications in the fields of medicine, agriculture, and materials science due to its unique properties and versatile reactivity.

InChI:InChI=1/C12H15NO/c14-12-7-6-11(8-9-13-12)10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,13,14)

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Relevant articles and documents

Pd-catalyzed stereoselective tandem ring-opening amination/cyclization of vinyl γ-lactones: Access to caprolactam diversity

A stereoselective amination/cyclization cascade process has been developed that allows for the preparation of a series of unsaturated and substituted caprolactam derivatives in good yields. This conceptually novel protocol takes advantage of the easy access and modular character of vinyl γ-lactones that can be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured ?-amino acid can be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlines the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way. This journal is

Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

A direct catalytic method is described for the α,β-desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic conditions. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups, showing reactivity complementary to that of prior desaturation methods. Lactams with various ring sizes and substituents at different positions all reacted smoothly. The synthetic utility of this method is demonstrated in a concise synthesis of Rolipram. In addition, linear amides also prove to be competent substrates, and the phthaloyl-protected product serves as a convenient precursor to access various conjugated carboxylic acid derivatives. Strong bases are avoided in this desaturation approach, and the key is to merge soft enolization with a Pd-catalyzed oxidation process.

Directing Group in Decarboxylative Cross-Coupling: Copper-Catalyzed Site-Selective C-N Bond Formation from Nonactivated Aliphatic Carboxylic Acids

Copper-catalyzed directed decarboxylative amination of nonactivated aliphatic carboxylic acids is described. This intramolecular C-N bond formation reaction provides efficient access to the synthesis of pyrrolidine and piperidine derivatives as well as the modification of complex natural products. Moreover, this reaction presents excellent site-selectivity in the C-N bond formation step through the use of directing group. Our work can be considered as a big step toward controllable radical decarboxylative carbon-heteroatom cross-coupling.