75001-47-7

Basic information

• Product Name: N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O)
• Synonyms: N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O);5'-Amino-2'-fluoroacetanilide;N-(5-Amino-2-fluorophenyl)acetamide, N3-Acetyl-4-fluorobenzene-1,3-diamine
• CAS NO: 75001-47-7
• Molecular Formula: C₈H₉FN₂O
• Molecular Weight: 168.1682632
• Mol File: 75001-47-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O)(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O)(75001-47-7)
• EPA Substance Registry System: N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O)(75001-47-7)

Safety Data

• Hazardous Substances Data: 75001-47-7(Hazardous Substances Data)

Usage

General Description

N-(5-amino-2-fluorophenyl)acetamide, also known as SALTDATA, is a chemical compound that exists in the form of a salt with 0.95 molecules of hydrochloric acid and 0.8 molecules of water. N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O) is an amide derivative with a fluoro-substituted phenyl group and an amino group attached to an acetamide moiety. It is commonly used in pharmaceutical research and development for its potential therapeutic applications, including its antimicrobial and antitumor properties. The presence of the salt form indicates that the compound is likely stable and suitable for use in pharmaceutical formulations and drug delivery systems.

Upstream product

• 454-07-9 N-(2-fluoro-5-nitrophenyl)acetamide 
• 369-36-8 6-fluoro-3-nitroaniline 

Downstream Products

• 113595-97-4 3-acetilamino-4-fluoroanilinometilenemalonato dietilico 
• 91524-15-1 Irloxacin 
• 62257-16-3 5-hydroxy-2-fluoroaniline 
• 521070-97-3 4'-fluoro-N-[6-fluoro-3-(1-pyrrolidinylmethyl)-7-quinolinyl]-[1,1'-biphenyl]-4-carboxamide 
• 521070-96-2 4-bromo-N-[6-fluoro-3-(1-pyrrolidinylmethyl)-7-quinolinyl]benzamide 
• 1092391-56-4 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo-[1,5-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide 
• 1092394-11-0 ethyl {[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-fluorophenoxy)pyridine-2-yl]carbamothioyl}carbamate 
• 1514914-63-6 C₁₇H₁₄BrFN₄O₂ 
• 1514914-97-6 C₁₇H₁₄ClFN₄O₂ 
• 1514914-92-1 C₁₁H₈BrFN₂O 
• 1514914-94-3 C₁₁H₈ClFN₂O 
• 1020173-38-9 2-fluoro-5-(6-nitropyridin-3-yloxy)benzenamine 
• 1005788-04-4 N-(2-fluoro-5-hydroxyphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide 
• 1092394-02-9 N-{2-fluoro-5-[(6-nitropyridin-3-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide 

Relevant articles and documents

Carbazole and Carboline Compounds for Use in the Diagnosis, Treatment, Alleviation or Prevention of Disorders Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.

Development of a scalable synthesis of a vascular endothelial growth factor receptor-2 kinase inhibitor: Efficient construction of a 6-etherified [1,2,4]triazolo[1,5-a]pyridine-2-amine Core

A practical and scalable synthesis of the vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibitor 1 has been developed. The key features of the process development include facile preparation of the key raw material 3-amino-4- fluorophenol, chemoselective nucleophilic aromatic substitution of 5-chloro-2-nitropyridine with phenol, a safe one-pot synthesis of a substituted urea using an isothiocyanate generated in situ from inexpensive materials, and improvement of the yield of acylation in the end game. The optimized six-step synthesis afforded 1·H2O in 54% overall yield, twice as much as the yield of the original synthesis, without chromatographic purification. In addition, a robust recrystallization procedure to afford the desired crystal form of 1 was also developed.

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