75012-63-4

Basic information

• Product Name: 1-acetyl-4-(o-fluorophenyl)piperazine
• Synonyms: 1-acetyl-4-(o-fluorophenyl)piperazine
• CAS NO: 75012-63-4
• Molecular Weight: 222.262
• Mol File: 75012-63-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-acetyl-4-(o-fluorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-4-(o-fluorophenyl)piperazine(75012-63-4)
• EPA Substance Registry System: 1-acetyl-4-(o-fluorophenyl)piperazine(75012-63-4)

Safety Data

• Hazardous Substances Data: 75012-63-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 1011-15-0 1-(o-fluorophenyl)piperazine 

Downstream Products

• 80743-05-1 2-{[3-(4-Acetyl-piperazin-1-yl)-4-fluoro-phenylamino]-methylene}-malonic acid diethyl ester 
• 75001-84-2 4-fluoro-3-(4-acetyl-1-piperazinyl)aniline 
• 75001-48-8 1-acetyl-4-(2-fluoro-5-nitrophenyl)piperazine 

Relevant articles and documents

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.