75014-44-7

Basic information

• Product Name: 3-triethoxycholesterol
• Synonyms: 3-triethoxycholesterol
• CAS NO: 75014-44-7
• Molecular Formula: C₃₃H₅₈O₄
• Molecular Weight: 0
• Mol File: 75014-44-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 593.1°C at 760 mmHg
• Flash Point: 312.5°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 1.54E-16mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 3-triethoxycholesterol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-triethoxycholesterol(75014-44-7)
• EPA Substance Registry System: 3-triethoxycholesterol(75014-44-7)

Safety Data

• Hazardous Substances Data: 75014-44-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C33H58O4/c1-24(2)7-6-8-25(3)29-11-12-30-28-10-9-26-23-27(37-22-21-36-20-19-35-18-17-34)13-15-32(26,4)31(28)14-16-33(29,30)5/h9,24-25,27-31,34H,6-8,10-23H2,1-5H3/t25-,27+,28+,29-,30+,31+,32+,33-/m1/s1

Upstream product

• 1182-65-6 cholesteryl p-toluenesulfonate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 57-88-5 cholesterol 
• 69502-33-6 2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate 
• 60221-37-6 8-(1H-tetrahydropyran-2-yloxy)-3n₆³-dioxaoctan-1-ol 
• 3381-54-2 cholesterol mesylate 

Downstream Products

• 75025-21-7 8-(5-cholesten-3β-yloxy)-3,6-dioxaoctyl p-toluenesulfonate 
• 890049-63-5 8-(cholest-5-en-3β-yloxy)-3,6-dioxaoctyl 2-azido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 
• 890049-64-6 8-(cholest-5-en-3β-yloxy)-3,6-dioxaoctyl 3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-α-D-galactopyranoside 
• 1325206-38-9 C₅₅H₇₂O₈ 
• 1325206-40-3 C₆₆H₈₆N₂O₁₁ 
• 1325206-41-4 C₆₂H₇₈N₂O₁₁ 

Relevant articles and documents

Preparation and application of brain glioma targeting berberine and folic acid modified lipid material

The invention discloses preparation and application of a brain glioma targeting berberine and folic acid modified lipid material, and can be used for preparing lipidosome modified by brain glioma targeting Tween 80 coated berberine and folic acid. The liposome surface is coated with Tween 80 and can pass through the blood-brain barrier effectively through receptor-mediated endocytosis after binding with low density lipoprotein receptors to deliver the drug to the brain. In addition, the liposome uses folic acid and berberine to modify brain glioma targeting and mitochondrial targeting capacity of the liposome, and the long chain of polyethylene glycol is introduced to stabilize the liposome. A new thought and a method can be provided for targeted therapy of glioma, and a wide application prospect is provided. pH MDR. The utility model can provide a new idea and a method for targeted therapy of brain glioma.

Biotin and membrane-penetrating peptide CO-mediated intelligent liposome material for breast cancer targeting (by machine translation)

The invention discloses a breast cancer targeting intelligent liposome material which is jointly mediated by biotin and a membrane penetrating peptide. After the liposome reaches the breast tumor part, PEG long-chain rupture of the hydrazone key is removed, and the short-chain-connected R8-mediated transmembrane is exposed, so that the effect of effectively treating the breast cancer is achieved through Michahael adducts. R8; 2; after the liposome reaches the mammary gland tumor site, the liposome is exposed out of the short-chain-linked immunostimulatory SMVT transposon. The novel intelligent lipid material can be used for different dosage forms including liposomes, nanoparticles, micelles and the like, and the prepared paclitaxel liposome has strong breast cancer penetration and treatment effects and has a wide application prospect. (by machine translation)

Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer

A series of liposome ligands (Bio-Chol, Bio-Bio-Chol, tri-Bio-Chol and tetra-Bio-Chol) modified by different branched biotins that can recognize the SMVT receptors over-expressed in breast cancer cells were synthesized. And four liposomes (Bio-Lip, Bio-Bio-Lip, tri-Bio-Lip and tetra-Bio-Lip) modified by above mentioned ligands as well as the unmodified liposome (Lip) were prepared to study the targeting ability for breast cancer. The cytotoxicity study and apoptosis assay of paclitaxel-loaded liposomes showed that tri-Bio-Lip had the strongest anti-proliferative effect on breast cancer cells. The cellular uptake studies on mice breast cancer cells (4T1) and human breast cancer cells (MCF-7) indicated tri-Bio-Lip possessed the strongest internalization ability, which was 5.21 times of Lip, 2.60 times of Bio-Lip, 1.67 times of Bio-Bio-Lip and 1.17 times of tetra-Bio-Lip, respectively. Moreover, the 4T1 tumor-bearing BALB/c mice were used to evaluate the in vivo targeting ability. The data showed the enrichment of liposomes at tumor sites were tri-Bio-Lip > tetra-Bio-Lip > Bio-Bio-Lip > Bio-Lip > Lip, which were consistent with the results of in vitro targeting studies. In conclusion, increasing the density of targeting molecules on the surface of liposomes can effectively enhance the breast cancer targeting ability, and the branching structure and spatial distance of biotin residues may also have an important influence on the affinity to SMVT receptors. Therefore, tri-Bio-Lip could be a promising drug delivery system for targeting breast cancer.