7504-49-6

Basic information

• Product Name: [4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium
• CAS NO: 7504-49-6
• Molecular Formula: C₁₂H₉N₃O₃
• Molecular Weight: 244.2256
• Mol File: 7504-49-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: [4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium(7504-49-6)
• EPA Substance Registry System: [4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium(7504-49-6)

Safety Data

• Hazardous Substances Data: 7504-49-6(Hazardous Substances Data)

Usage

Description

[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium is a chemical compound belonging to the diazeniumdiolate class. It functions as a nitric oxide donor, capable of releasing nitric oxide under physiological conditions. Nitric oxide is a vital signaling molecule involved in various biological processes such as vasodilation, neurotransmission, and immune response modulation.

Uses

Used in Cardiovascular Applications:
[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium is used as a therapeutic agent for cardiovascular diseases due to its ability to release nitric oxide, which aids in vasodilation and improves blood flow.
Used in Inflammatory Disorders:
In the treatment of inflammatory disorders, [4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium is used as an anti-inflammatory agent. The released nitric oxide can modulate the immune response and reduce inflammation.
Used in Neurodegenerative Diseases:
[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium is used as a potential therapeutic agent for neurodegenerative diseases. The nitric oxide released by this compound can play a role in neurotransmission and may help protect neurons from degeneration.
Used in Pharmaceutical Development:
In the pharmaceutical industry, [4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-oxobutylidene]diazenium is used as a key compound for the development of novel therapeutics with nitric oxide-mediated effects. Its unique properties make it a promising candidate for creating new drugs targeting various medical conditions.

Upstream product

• 3339-73-9 3-phthalimidopropanoic acid 
• 186581-53-3 diazomethane 
• 17137-11-0 3-phthalimidopropionyl chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 39739-03-2 4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-butyric acid methyl ester 
• 51132-00-4 2-(4-bromo-3-oxobutyl)isoindoline-1,3-dione 
• 89587-22-4 2-[3-(4,6-Dioxo-5-phenyl-1,3a,4,5,6,6a-hexahydro-pyrrolo[3,4-c]pyrazol-3-yl)-3-oxo-propyl]-isoindole-1,3-dione 
• 3130-75-4 4-phthalimidobutyric acid 
• 41306-64-3 2-(5-bromo-4-oxo-pentyl)-isoindole-1,3-dione 
• 102442-31-9 2-(4-dimethylamino-phenylimino)-3-oxo-6-phthalimido-hexanenitrile 
• 1253176-62-3 2-(3-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-oxopropyl)-1H-indene-1,3(2H)-dione 
• 1253176-47-4 2-(3-((2S,3S)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-oxopropyl)-1H-indene-1,3(2H)-dione 
• 1253176-63-4 2-(3-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-cyclohexylaziridin-2-yl)-3-oxopropyl)-1H-indene-1,3(2H)-dione 
• 1253176-48-5 2-(3-((2S,3S)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-cyclohexylaziridin-2-yl)-3-oxopropyl)-1H-indene-1,3(2H)-dione 

Relevant articles and documents

Trimethylsilyldiazomethane as a versatile stitching agent for the introduction of aziridines into functionalized organic molecules

A highly enantioselective route for the introduction of aziridines into functionalized organic molecules was developed via a tandem acylation and aziridination of TMSCHN2.

Sulfur ylides 10. Modified method for the synthesis of pyrrolizine- and indolizinediones

A modified method for the synthesis of derivatives of pyrrolizinedione and iridolizinedione was proposed. The method is based on the intramolecular cyclization of keto-stabilized sulfur ylides generated in situ from diazo ketones and Me2S in the presence of Rh2(OAc)4.