7504-58-7Relevant articles and documents
Accelerating reactions with microreactors at elevated temperatures and pressures: Profiling aminocarbonylation reactions
Murphy, Edward R.,Martinelli, Joseph R.,Zaborenko, Nikolay,Buchwald, Stephen L.,Jensen, Klavs F.
, p. 1734 - 1737 (2007)
Squeeze play: Pressurized microreactor systems greatly expand the range of reaction conditions and accelerate gas-liquid mass transfer. Heck aminocarbonylation reactions (see scheme) exemplify the potential for the quick and safe scanning of reagents and
Direct Amidation of Esters by Ball Milling**
Barreteau, Fabien,Battilocchio, Claudio,Browne, Duncan L.,Godineau, Edouard,Leitch, Jamie A.,Nicholson, William I.,Payne, Riley,Priestley, Ian
supporting information, p. 21868 - 21874 (2021/09/02)
The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.
Synthesis method of amide compound
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Paragraph 0096; 0097, (2020/09/09)
The invention discloses a synthesis method of an amide compound. The synthesis method comprises the following step: carrying out a photocatalytic reaction on benzyl alcohol with a structure as shown in a formula (I) and an amine compound with a structure as shown in a formula (II) in the presence of photocatalyst-loaded metal P-C3N4 by using an organic solvent as a medium to obtain the amide compound with a structure as shown in a formula (III). The synthesis method does not need a heat source for heat supply, avoids high-temperature reaction, is simple to operate, short in reaction time and simple in aftertreatment, and can easily realize industrial production.