7506-46-9

Basic information

• Product Name: N-cyclohexyl-4-nitrobenzamide
• Synonyms: N-cyclohexyl-4-nitrobenzamide;MFCD00439005
• CAS NO: 7506-46-9
• Molecular Formula: C₁₃H₁₆N₂O₃
• Molecular Weight: 248.27774
• Mol File: 7506-46-9.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 450.6°C at 760 mmHg
• Flash Point: 226.3°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 2.6E-08mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: N-cyclohexyl-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-4-nitrobenzamide(7506-46-9)
• EPA Substance Registry System: N-cyclohexyl-4-nitrobenzamide(7506-46-9)

Safety Data

• Hazardous Substances Data: 7506-46-9(Hazardous Substances Data)

Usage

General Description

N-cyclohexyl-4-nitrobenzamide is a chemical compound with the molecular formula C13H15N3O3. It is a yellow crystalline solid that is insoluble in water but soluble in organic solvents. N-cyclohexyl-4-nitrobenzamide is commonly used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential biological activity, including its role in the inhibition of protein kinase C and its potential as a therapeutic agent for the treatment of cancer and other diseases. Additionally, N-cyclohexyl-4-nitrobenzamide has been utilized in research and development for its ability to modulate cellular signaling pathways and its potential in drug discovery.

InChI:InChI=1/C13H16N2O3/c16-13(14-11-4-2-1-3-5-11)10-6-8-12(9-7-10)15(17)18/h6-9,11H,1-5H2,(H,14,16)

Upstream product

• 108-91-8 cyclohexylamine 
• 122-04-3 4-nitro-benzoyl chloride 
• 115127-49-6 3-bromo-3-(4-nitrophenyl)diazirine 
• 105398-69-4 Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 83539-70-2 N-p-nitrobenzoyl-2-phenyliminooxazolidine 
• 80478-52-0 N-benzyl-8-S-(p-nitrobenzoyl)dihydrolipoamide 
• 62-23-7 4-nitro-benzoic acid 
• 538-75-0 dicyclohexyl-carbodiimide 
• 13277-61-7 p-Nitrobenzoyl bromide 
• 555-16-8 4-nitrobenzaldehdye 
• 931-53-3 Cyclohexyl isocyanide 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 622-45-7 cyclohexyl acetate 

Downstream Products

• 17675-42-2 4-amino-N-cyclohexylbenzamide 
• 59507-51-6 4-(N-cyclohexyl-amino-methyl)-nitrobenzene 
• 42974-61-8 (E)-N-cyclohexyl-1-(4-nitrophenyl)methanimine 
• 555-16-8 4-nitrobenzaldehdye 
• 3758-70-1 1-(4-nitrophenyl)propan-1-one 
• 157846-99-6 (1-methyl-1H-pyrrol-2-yl)-(4-nitrophenyl)-methanone 

Relevant articles and documents

Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis

Sepsis, a systemic inflammatory response, caused by pathogenic factors including microorganisms, has high mortality and limited therapeutic approaches. Herein, a new soluble epoxide hydrolase (sEH) inhibitor series comprising a phenyl ring connected to a

Nickel-catalyzed reductive amidation of aryl-triazine ethers

The reaction of activated phenolic compounds, 2,4,6-triaryloxy-1,3,5-triazine (aryl-triazine ethers), with various isocyanates or carbodiimides in the presence of a nickel pre-catalyst resulted in the synthesis of aryl amides in good to excellent yields.

Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.