7509-13-9

Basic information

• Product Name: 1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
• Synonyms: 1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID;IFLAB-BB F3207-0037;1,2-Dihydro-1-oxoisoquinoline-3-carboxylic acid
• CAS NO: 7509-13-9
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Mol File: 7509-13-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 469.7°C at 760 mmHg
• Flash Point: 237.8°C
• Appearance: /
• Density: 1.429g/cm³
• Vapor Pressure: 1.27E-09mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID(7509-13-9)
• EPA Substance Registry System: 1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID(7509-13-9)

Safety Data

• Hazardous Substances Data: 7509-13-9(Hazardous Substances Data)

Usage

General Description

1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is a chemical compound with the molecular formula C11H9NO3. It is a derivative of isoquinoline, a heterocyclic compound that consists of a benzene ring fused to a pyridine ring. 1-OXO-1,2-DIHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is a carboxylic acid, containing a functional group composed of a carbonyl group and a hydroxyl group. It is commonly used in organic synthesis and as a building block for the preparation of pharmaceuticals and other biologically active compounds. This chemical may also possess pharmacological properties and may be used as a research tool in the development of new drugs and therapies.

InChI:InChI=1/C10H7NO3/c12-9-7-4-2-1-3-6(7)5-8(11-9)10(13)14/h1-5H,(H,11,12)(H,13,14)

Upstream product

• 2289-03-4 1-oxo-1H-isochromene-3-carboxylic acid 
• 4361-85-7 1-oxo-1H-isothiochromene-3-carboxylic acid 
• 847783-41-9 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester 
• 100727-89-7 1-hydroxy-isoquinoline-3,4-dicarboxylic acid-4-ethyl ester 
• 88590-43-6 (Z)-methyl 2-[(5-oxo-2-phenyloxazol-4(5H)-ylidene)-methyl]-benzoate 
• 14961-34-3 diethyl homophthalate 
• 56661-83-7 2-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-benzoic acid 
• 41234-80-4 1-oxo-1H-isochromene-3,4-dicarboxylic acid 4-ethyl ester 
• 101094-24-0 3,4-Diethoxycarbonyl-isocumarin 
• 69454-42-8 methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate 

Downstream Products

• 119-65-3 isoquinoline 
• 94726-24-6 ethyl 1-hydroxyisoquinoline-3-carboxylate 
• 491-30-5 1-hydroxyisoquinoline 
• 1090010-40-4 N-benzyl-1-oxo-1,2-dihydroisoquinoline-3-carboxamide 

Relevant articles and documents

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

VIRAL AND FUNGAL INHIBITORS

Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus, and fungal infections such as, for example, candidiasis.

The practical use of a glycine anion equivalent for the preparation of 3-carboxy-1,2-dihydro-1-oxoisoquinoline

Reaction of the dianion derived from N-Cbz-glycine ethyl ester with 2- carboxybenzaldehyde gave the 2-(phthalidyl)glycinate derivative 8 as the major product. Successive treatment of the latter with LiOH and CF3CO2H/CF3SO