94726-24-6

Basic information

• Product Name: Ethyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate
• Synonyms: Ethyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate
• CAS NO: 94726-24-6
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.22064
• Mol File: 94726-24-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 443.276°C at 760 mmHg
• Flash Point: 221.885°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate(94726-24-6)
• EPA Substance Registry System: Ethyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate(94726-24-6)

Safety Data

• Hazardous Substances Data: 94726-24-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11NO3/c1-2-16-12(15)10-7-8-5-3-4-6-9(8)11(14)13-10/h3-7H,2H2,1H3,(H,13,14)

Upstream product

• 7509-13-9 1-hydroxy-isoquinoline-3-carboxylic acid 
• 847783-41-9 1-hydroxy-isoquinolin-3-orthocarboxylic acid trimethyl ester 
• 88590-43-6 (Z)-methyl 2-[(5-oxo-2-phenyloxazol-4(5H)-ylidene)-methyl]-benzoate 
• 116922-17-9 ethyl α-ethoxy-2-carbamoylcinnamate 
• 119-67-5 o-carboxybenzaldehyde 
• 4387-36-4 2-iodobenzonitrile 
• 116922-16-8 ethyl α-ethoxy-2-cyanocinnamate 
• 64-17-5 ethanol 
• 69454-42-8 methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 201230-82-2 carbon monoxide 
• 906365-32-0 (S)-ethyl 3-phenyl-2-(picolinamido)propanoate 

Downstream Products

• 1079947-40-2 ethyl 1-bromoisoquinoline-3-carboxylate 
• 1256353-08-8 ethyl 1-chloroisoquinoline-3-carboxylate 
• 1362689-45-9 (1-chloroisoquinolin-3-yl)(4-fluorophenyl)methanone 
• 1362689-46-0 tert-butyl 3-(3-(4-fluorobenzoyl)isoquinolin-1-ylamino)-5-methyl-1H-pyrazole-1-carboxylate 
• 1362689-16-4 (4-fluorophenyl)(1-(5-methyl-1H-pyrazol-3-ylamino)isoquinolin-3-yl)methanol 
• 1362689-15-3 (4-fluorophenyl)(1-(5-methyl-1H-pyrazol-3-ylamino)isoquinolin-3-yl)methanone 

Relevant articles and documents

Cobalt-Catalyzed C(sp2)-H Carbonylation of Amino Acids Using Picolinamide as a Traceless Directing Group

Herein we report an efficient protocol for the C(sp2)-H carbonylation of amino acid derivatives based on an inexpensive cobalt(II) salt catalyst. Carbonylation was accomplished using picolinamide as a traceless directing group, CO (1 atm) as the carbonyl

QUINOLINE AND ISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds a

The practical use of a glycine anion equivalent for the preparation of 3-carboxy-1,2-dihydro-1-oxoisoquinoline

Reaction of the dianion derived from N-Cbz-glycine ethyl ester with 2- carboxybenzaldehyde gave the 2-(phthalidyl)glycinate derivative 8 as the major product. Successive treatment of the latter with LiOH and CF3CO2H/CF3SO