75127-50-3

Basic information

• Product Name: N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide
• Synonyms: N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide
• CAS NO: 75127-50-3
• Molecular Weight: 381.452
• Mol File: 75127-50-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide(75127-50-3)
• EPA Substance Registry System: N-[2-(4-methoxybenzoyl)phenyl]-4-(methyl)benzenesulfonamide(75127-50-3)

Safety Data

• Hazardous Substances Data: 75127-50-3(Hazardous Substances Data)

Upstream product

• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 100-66-3 methoxybenzene 
• 98-59-9 p-toluenesulfonyl chloride 
• 118-92-3 anthranilic acid 
• 42840-02-8 2-(Toluene-4-sulfonylamino)-benzoyl chloride 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 696-62-8 para-iodoanisole 

Downstream Products

• 36192-61-7 2-amino-4'-methoxybenzophenone 
• 1351557-19-1 11-(4-methoxyphenyl)-6-methyl-6H-indolo[2,3-b]quinoline 
• 500870-86-0 4-(aminosulfonyl)-N-[2-(4-methoxybenzoyl)phenyl]benzamide 
• 565452-82-6 2-(4-aminosulfonylphenyl)-3-(4-hydroxyphenyl)indole 
• 500870-96-2 2-[4-(aminosulfonyl)phenyl]-3-(4-methoxyphenyl)-1H-indole 
• 500870-85-9 N-[2-(4-methoxybenzoyl)phenyl]-4-(methylsulfonyl)benzamide 

Relevant articles and documents

Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C–H Arylations with Aryl Halides

A rhodium-catalyzed general protocol for the directing-group-assisted arylation of aromatic aldehydic C–H bonds was developed. This method involves either hydroxy- or amino-group-directed aldehyde C–H arylation with various aryl halides. A broad synthetic scope for the preparation of 2-hydroxybenzophenones was established with electronically variant salicylaldehydes and aryl halides with chemo- and regioselective possibilities. The developed protocol was also applied in the synthesis of medicinally important 3-salicyloylpyridines in high yields.

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: A new series of selective COX-2 inhibitors

A new series of substituted 2-sulfonyphenyl-3-phenyl-indole derivatives were synthesized and evaluated for their ability to inhibit COX-2 and COX-1enzymes. Most of the compounds synthesized were found to be highly potent and selective inhibitors of COX-2. This work led to the discovery of 2-aminosulfonylphenyl-3-phenyl-indole 5a which possesses higher activity and selectivity for COX-2 than Celecoxib both in vitro and in vivo.