75150-40-2

Basic information

• Product Name: 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE
• Synonyms: 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE;AURORA 22084;S-(4-CHLOROPHENYLTHIO)ACETHYDRAZIDE;TIMTEC-BB SBB002377;2-[(4-Chlorophenyl)thio]acetohydrazide;(4-Chloro-phenylsulfanyl)-acetic acid hydrazide;[(4-Chlorophenyl)thio]acetic acid hydrazide
• CAS NO: 75150-40-2
• Molecular Formula: C₈H₉ClN₂OS
• Molecular Weight: 216.69
• Mol File: 75150-40-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 103-104
• Boiling Point: 419.4 °C at 760 mmHg
• Flash Point: 207.4 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 3.05E-07mmHg at 25°C
• Refractive Index: 1.636
• PKA: 12.13±0.37(Predicted)
• CAS DataBase Reference: 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE(75150-40-2)
• EPA Substance Registry System: 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE(75150-40-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 75150-40-2(Hazardous Substances Data)

Usage

General Description

2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE is a chemical compound with the molecular formula C8H9ClN2OS. It is an acetohydrazide derivative with a chlorophenylsulfanyl group attached to the acetylhydrazine moiety. 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE has been studied for its potential pharmaceutical properties, including its antibacterial and antifungal activities. It has also been investigated for its potential use in the treatment of tuberculoses and other infectious diseases. The chemical structure and properties of 2-[(4-CHLOROPHENYL)SULFANYL]ACETOHYDRAZIDE make it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C8H9ClN2OS/c9-6-1-3-7(4-2-6)13-5-8(12)11-10/h1-4H,5,10H2,(H,11,12)

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 106-54-7 p-Chlorothiophenol 
• 52377-68-1 ethyl 2-(p-chlorophenylthio)acetate 

Downstream Products

• 81863-62-9 N-1-(4'-chlorophenylthioacetyl)-N-4-(4-methylphenyl)thiosemicarbazide 
• 81863-61-8 C₁₅H₁₄ClN₃OS₂ 
• 81863-65-2 C₁₅H₁₃Cl₂N₃OS₂ 
• 81863-63-0 C₁₆H₁₆ClN₃O₂S₂ 
• 81877-72-7 C₁₅H₁₃Cl₂N₃OS₂ 
• 81863-64-1 C₁₇H₁₈ClN₃O₂S₂ 
• 81877-70-5 C₁₆H₁₆ClN₃O₂S₂ 
• 81877-71-6 C₁₇H₁₈ClN₃O₂S₂ 
• 72930-61-1 8-Chloro-6-(2-chloro-phenyl)-1-(4-chloro-phenylsulfanylmethyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene 
• 81863-66-3 C₁₅H₁₃BrClN₃OS₂ 
• 155776-08-2 5-(4-Chloro-phenylsulfanylmethyl)-4-phenylamino-4H-[1,2,4]triazole-3-thiol 
• 155776-19-5 4-[5-(4-Chloro-phenylsulfanylmethyl)-4-phenylamino-4H-[1,2,4]triazol-3-ylsulfanyl]-5-methyl-2,4-dihydro-pyrazol-3-one 
• 155776-55-9 4-Bromo-4-[5-(4-chloro-phenylsulfanylmethyl)-4-phenylamino-4H-[1,2,4]triazol-3-ylsulfanyl]-5-methyl-2,4-dihydro-pyrazol-3-one 
• 155777-27-8 5-[5-(4-Chloro-phenylsulfanylmethyl)-4-phenylamino-4H-[1,2,4]triazol-3-ylsulfanyl]-pyrimidine-2,4,6-trione 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

Disulfide derivative containing 1,3,4-oxa(thia)diazole and preparation method and application of derivative

The invention discloses a disulfide derivative containing 1,3,4-oxa(thia)diazole and a preparation method and application of the derivative. The disulfide derivative has the following general formula (as shown in the specification), wherein R1 is selected from 4-chlorphenyl, 4-fluoro-phenyl, benzyl, 4-chloro-benzyl and other substituent groups; R2 is selected from methyl, ethyl, benzyl, 4-chloro-benzyl, ethyl acetate and other substituent groups; X is O or S. The disulfide derivative disclosed by the invention can serve as a medicine or agent for killing nematodes and inhibiting crop bacterium diseases.

Synthesis of some new thiosemicarbazides, thiadiazoles, triazoles and their derivatives as potential antiviral agents

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