75188-06-6

Basic information

• Product Name: 2-chloro-2-(4-chlorophenyl)acetyl chloride
• Synonyms: 2-chloro-2-(4-chlorophenyl)acetyl chloride
• CAS NO: 75188-06-6
• Molecular Weight: 223.486
• Mol File: 75188-06-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-2-(4-chlorophenyl)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-2-(4-chlorophenyl)acetyl chloride(75188-06-6)
• EPA Substance Registry System: 2-chloro-2-(4-chlorophenyl)acetyl chloride(75188-06-6)

Safety Data

• Hazardous Substances Data: 75188-06-6(Hazardous Substances Data)

Upstream product

• 7138-34-3 p-chloromandelic acid 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 4674-24-2 2-(4-chlorophenyl)-2-methoxyacetic acid 
• 104180-02-1 2,2'-bis-(4-chloro-phenyl)-2,2'-oxy-di-acetic acid-dianilide 
• 67447-60-3 chloro-(4-chloro-phenyl)-acetic acid methyl ester 
• 70232-14-3 2-chloro-2-(4-chlorophenyl)acetamide 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.