75279-53-7 Usage
Description
4-Chloro-2-fluorophenylacetonitrile, also known as 4-Chloro-2-fluorobenzeneacetonitrile, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its molecular structure, which includes a chlorine atom at the 4th position and a fluorine atom at the 2nd position on a benzene ring, with an acetonitrile group attached to the side chain.
Uses
Used in Pharmaceutical Industry:
4-Chloro-2-fluorophenylacetonitrile is used as an intermediate for the preparation of RG7388, a potent and selective p53-MDM2 inhibitor. 4-Chloro-2-fluorophenylacetonitrile plays a significant role in the development of cancer therapeutics, as it helps in the synthesis of a drug that targets the p53-MDM2 interaction, which is a critical pathway in tumor suppression and cell cycle regulation.
In addition to its use in the pharmaceutical industry, 4-Chloro-2-fluorophenylacetonitrile may also find applications in other industries, such as:
Used in Chemical Synthesis Industry:
4-Chloro-2-fluorophenylacetonitrile can be used as a building block for the synthesis of various other organic compounds, including dyes, agrochemicals, and specialty chemicals. Its unique molecular structure with a chlorine and fluorine atom on the benzene ring provides a versatile platform for further chemical modifications and functionalization.
Used in Research and Development:
In the field of research and development, 4-Chloro-2-fluorophenylacetonitrile can be employed as a starting material for the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various fields, such as materials science, medicinal chemistry, and environmental chemistry.
Overall, 4-Chloro-2-fluorophenylacetonitrile is a valuable compound with diverse applications, particularly in the pharmaceutical industry for the development of cancer therapeutics, as well as in chemical synthesis and research and development for the creation of new compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 75279-53-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,2,7 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 75279-53:
(7*7)+(6*5)+(5*2)+(4*7)+(3*9)+(2*5)+(1*3)=157
157 % 10 = 7
So 75279-53-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5ClFN/c9-7-2-1-6(3-4-11)8(10)5-7/h1-2,5H,3H2
75279-53-7Relevant articles and documents
Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes
Hu, Dandan,Liu, Jiayue,Ren, Hongjun,Song, Jinyu,Zhang, Jun-Qi,Zhu, Guorong
supporting information, p. 786 - 790 (2022/01/28)
A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reacti
PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES
-
Page/Page column 41, (2015/02/02)
Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.
ELECTRFLUORATION EN POSITION BENZYLIQUE DANS LE SULFOLANE
Laurent, Eliane,Marquet, Bernard,Tardivel, Robert
, p. 115 - 126 (2007/10/02)
The use of sulfolane as a solvent instead of acetonitrile in the electrofluorination of benzylic derivatives 1, (R=H, Cl) gives greater yields of benzylic fluorides 2, since the formation of acetamide byproducts 4 is prevented.However, the parallel fluorination of the aromatic nucleus is not avoided under these conditions.
