87417-71-8

Basic information

• Product Name: 4-CHLORO-2-FLUOROBENZYL CHLORIDE
• Synonyms: 4-CHLORO-2-FLUOROBENZYL CHLORIDE;2-FLUORO-4-CHLOROBENZYL CHLORIDE;4-Chloro-1-(chloromethyl)-2-fluorobenzene;4-Chloro-1-(chloromethyl)-2-fluorobenzene, alpha,4-Dichloro-2-fluorotoluene;4-CHLORO-2-FLUOROBENZYL CHLORID
• CAS NO: 87417-71-8
• Molecular Formula: C7H5Cl2F
• Molecular Weight: 179.02
• Product Categories: Fluorine series
• Mol File: 87417-71-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 208.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.343±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Lachrymatory
• CAS DataBase Reference: 4-CHLORO-2-FLUOROBENZYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-FLUOROBENZYL CHLORIDE(87417-71-8)
• EPA Substance Registry System: 4-CHLORO-2-FLUOROBENZYL CHLORIDE(87417-71-8)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 87417-71-8(Hazardous Substances Data)

Usage

Description

4-Chloro-2-fluorobenzyl Chloride is an organic compound characterized by the presence of a chlorine atom at the 4th position and a fluorine atom at the 2nd position on a benzene ring, with a chlorine atom attached to the benzyl group. It is a versatile reagent in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-fluorobenzyl Chloride is used as a reagent for the alternate synthesis of a Janus kinase 2 (JAK2) inhibitor intermediate. This intermediate plays a crucial role in the development of JAK2 inhibitors, which are important for the treatment of various inflammatory and autoimmune diseases.
Used in Agrochemical Industry:
4-Chloro-2-fluorobenzyl Chloride is also used as a reagent in the synthesis of agrochemicals, specifically in the preparation of active ingredients for pesticides and herbicides. Its unique structure allows for the development of novel compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Organic Synthesis:
In addition to its applications in the pharmaceutical and agrochemical industries, 4-Chloro-2-fluorobenzyl Chloride is a valuable reagent in organic synthesis. Its reactive chlorine atom allows for various chemical transformations, such as nucleophilic substitution, addition reactions, and coupling reactions, making it a useful building block for the synthesis of complex organic molecules.

InChI:InChI=1S/C7H5Cl2F/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2

Upstream product

• 56456-49-6 (4-chloro-2-fluorophenyl)methanol 
• 452-75-5 4-chloro-2-fluorotoluene 

Downstream Products

• 75279-53-7 2-(4-chloro-2-fluoro-phenyl)acetonitrile 

Relevant articles and documents

Preparation method for 4-chloro-2-fluoro-phenylpropionic acid

The invention relates to the technical field of chemical synthesis, in particular to a preparation method for 4-chloro-2-fluoro-phenylpropionic acid. The preparation method is characterized in that cheap and easily-available 4-chloro-2-fluorotoluene is ta