7533-25-7

Basic information

• Product Name: rac 2,4-O-Dimethylzearalenone
• Synonyms: rac 2,4-O-Dimethylzearalenone;(+/-)-Zearalenone DiMethyl Ether;3,4,5,6,9,10-Hexahydro-14,16-diMethoxy-3-Methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
• CAS NO: 7533-25-7
• Molecular Formula: C20H26O5
• Molecular Weight: 346.41744
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 7533-25-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: rac 2,4-O-Dimethylzearalenone(CAS DataBase Reference)
• NIST Chemistry Reference: rac 2,4-O-Dimethylzearalenone(7533-25-7)
• EPA Substance Registry System: rac 2,4-O-Dimethylzearalenone(7533-25-7)

Safety Data

• Hazardous Substances Data: 7533-25-7(Hazardous Substances Data)

Usage

Uses

Protected rac Zearalenone

Upstream product

• 78647-44-6 (E)-11-Hydroxy-2,4-dimethoxy-7-methyl-5-oxo-7,8,9,10,11,12,13,14-octahydro-5H-6-oxa-benzocyclotetradecene-11-carbonitrile 
• 84574-18-5 2,4-Dimethoxy-7-methyl-16-phenylsulfanyl-7,8,9,10,13,14,15,16-octahydro-12H-6-oxa-benzocyclotetradecene-5,11-dione 
• 78773-31-6 1-(3,5-dimethoxy-6-carboxyphenyl)-10-methylsulfonate-1-undecene 6-ethylene ketal 
• 312305-42-3 2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-5-oxo-dec-9-enyl ester 
• 17846-96-7 10-hydroxy-undec-1-en-6-one 
• 823-22-3 5-hexanolide 
• 312305-40-1 2-hydroxy-4,6-dimethoxybenzoic acid 1-methyl-5-oxo-dec-9-enyl ester 
• 312305-41-2 2,4-dimethoxy-6-trifluoromethanesulfonyloxy-benzoic acid 1-methyl-5-oxo-dec-9-enyl ester 
• 10497-40-2 2,4-Dimethoxy-zearalenone 
• 17851-58-0 2-{(E)-5-[2-(4-Hydroxy-pentyl)-[1,3]dioxolan-2-yl]-pent-1-enyl}-4,6-dimethoxy-benzoic acid 
• 17924-92-4 zearalenone 
• 16320-11-9 (S)-(-)-zearalenone dimethyl ether ethylene glycol 
• 764-59-0 hex-5-en-1-al 
• 78647-39-9 2-((E)-5-Hydroxy-pent-1-enyl)-4,6-dimethoxy-benzoic acid 1-methyl-5-oxo-pentyl ester 

Downstream Products

• 17194-80-8 Zearalenone Dimethyl Ether 

Relevant articles and documents

Synthesis and cytotoxic activities of semisynthetic zearalenone analogues

Zearalenone is a β-resorcylic acid macrolide with various biological activities. Herein we report the synthesis and cytotoxic activities of 34 zearalenone analogues against human oral epidermoid carcinoma (KB) and human breast adenocarcinoma (MCF-7) cells as well as noncancerous Vero cells. Some zearalenone analogues showed moderately enhanced cytotoxic activities against the two cancer cell lines. We have discovered the potential lead compounds with diminished or no cytotoxicity to Vero cells. Preliminary structure–activity relationship studies revealed that the double bond at the 1′ and 2′ positions of zearalenone core was crucial for cytotoxic activities on both cell lines. In addition, for zearalenol analogues, the unprotected hydroxyl group at C-2 and an alkoxy substituent at C-4 played key roles on cytotoxic effects of both cell lines.

A concise total synthesis of (S)-zearalenone and zeranol

A convergent total synthesis of the naturally occurring, 14-membered macrolides (S)-zearalenone and zeranol has been achieved through application of the Diels-Alder reaction, Jacobsen kinetic resolution, Mitsunobu coupling, ring-closing metathesis, and hy

Total syntheses of (S)-(-)-zearalenone and lasiodiplodin reveal superior metathesis activity of ruthenium carbene complexes with imidazol-2-ylidene ligands

Total syntheses of the bioactive orsellinic acid derivatives zearalenone 3 and lasiodiplodin 1 are reported based on a ring-closing metathesis (RCM) reaction of styrene precursors as the key steps. These and closely related macrocyclizations are catalyzed