7536-59-6

Basic information

• Product Name: BOC-GLU(OBZL)-ONP
• Synonyms: BOC-L-GLUTAMIC ACID-GAMMA-BENZYL-ALPHA-P-NITROPHENYL-DIESTER;BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER P-NITROPHENYL ESTER;BOC-L-GLUTAMIC ACID GAMMA-BENZYL-ALPHA-4-NITROPHENYL DI-ESTER;BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-4-NITROPHENYL ESTER;BOC-L-GLUTAMIC ACID 5-BENZYL 1-(4-NITROPHENYL) ESTER;BOC-GLUTAMIC ACID(OBZL)-ONP;BOC-GLU(OBZL)-ONP;N-tert-Butoxycarbonyl-L-glutamic acid 5-benzyl ALPHA-(4- nitrophenyl)-ester
• CAS NO: 7536-59-6
• Molecular Formula: C₂₃H₂₆N₂O₈
• Molecular Weight: 458.46
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 7536-59-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 618.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.258±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.62±0.46(Predicted)
• CAS DataBase Reference: BOC-GLU(OBZL)-ONP(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-GLU(OBZL)-ONP(7536-59-6)
• EPA Substance Registry System: BOC-GLU(OBZL)-ONP(7536-59-6)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 7536-59-6(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 117997-81-6 5-(benzyloxy)-2-(tert-butoxycarbonylamino)-5-oxopentanoic acid 
• 13574-13-5 Boc-Glu(OBzl)-OH 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 13303-10-1 tert-Butyl 4-nitrophenyl carbonate 

Downstream Products

• 122668-41-1 benzyl (S)-4-((tert-butoxycarbonyl)amino)-5-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-5-oxopentanoate 
• 124980-38-7 Boc-Glu(OBzl)-Gly-OMse 
• 124980-39-8 Boc-Glu(OBzl)-Gly-OTse 
• 124980-40-1 Boc-Glu(OBzl)-Gly-OPse 
• 131697-24-0 Boc-Glu(OBzl)-Gly-OMe 
• 131696-95-2 Boc-Glu(OBzl)-Phe-Gly-OMe 
• 111854-51-4 Boc-Glu(OBzl)-Ala-Phe-NH₂ 
• 116084-66-3 Boc-Glu(OBzl)-Phe-Phe-Phe-OEt 
• 115545-70-5 Boc-Glu(OBzl)-Asp(O-2-Ada)-Gly-OBzl 
• 88831-90-7 Boc-Glu(OBzl)-Cys(MBzl)-Lys(Z)-Cys(MBzl)-Thr-Ser-OBzl 
• 101854-33-5 Boc-Glu(OBzl)-Lys(Z)-Glu(OBzl)-Arg(Mts)-Asn-Lys(Z)-Gly-Gln-OBzl 
• 103584-80-1 Boc-Glu(OBzl)-Cys(MBzl)-Lys(Z)-Cys(MBzl)-Thr-Ser-Cys(MBzl)-OBzl 
• 89762-72-1 Boc-Glu(OBzl)-Ser-Leu-Ile-NH₂ 
• 78233-10-0 Boc-Glu(OBzl)-Arg(Mts)-Val-NHNH-Troc 

Relevant articles and documents

SYNTHESIS OF POLY(ETHYLENE GLYCOL) BLOCK COPOLYMERS AS POTENTIAL WATER-SOLUBLE DRUG CARRIERS

The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described.In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer.The oligopeptides used were potential substrates for chymotrypsin.The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation of chymotrypsin solution is discussed in detail.The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.