7537-09-9

Basic information

• Product Name: 4,5-dimethoxy-2-methylbenzyl cyanide
• Synonyms: 4,5-dimethoxy-2-methylbenzyl cyanide
• CAS NO: 7537-09-9
• Molecular Weight: 191.23
• Mol File: 7537-09-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4,5-dimethoxy-2-methylbenzyl cyanide(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethoxy-2-methylbenzyl cyanide(7537-09-9)
• EPA Substance Registry System: 4,5-dimethoxy-2-methylbenzyl cyanide(7537-09-9)

Safety Data

• Hazardous Substances Data: 7537-09-9(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 494-99-5 1,2-dimethoxy-4-methylbenzene 
• 7537-05-5 1-(chloromethyl)-4,5-dimethoxy-2-methylbenzene 
• 143-33-9 sodium cyanide 
• 50-00-0 formaldehyd 
• 151-50-8 potassium cyanide 

Downstream Products

• 31706-96-4 (E)-2-(4,5-Dimethoxy-2-methyl-phenyl)-5-(3,4-dimethoxy-phenyl)-pent-4-enenitrile 
• 7537-13-5 2-(4,5-Dimethoxy-2-methyl-phenyl)-3-oxo-butyronitrile 
• 31707-12-7 3-Bromo-4-(3,4-dimethoxy-phenyl)-5,6-dimethoxy-8-methyl-naphthalene-1-carbonitrile 
• 31706-93-1 8-Bromomethyl-5,6-dimethoxy-4-phenyl-naphthalene-1-carbonitrile 
• 31706-94-2 5,6-Dimethoxy-8-methyl-4-phenyl-naphthalene-1-carboxylic acid amide 
• 31706-92-0 5,6-Dimethoxy-8-methyl-4-phenyl-naphthalene-1-carbonitrile 
• 7652-98-4 1-(4,5-Dimethoxy-2-methyl-phenyl)-propan-2-one 
• 117661-82-2 2-[2-(4,5-Dimethoxy-2-methyl-phenyl)-ethyl]-4,5-dimethoxy-isoindole-1,3-dione 
• 117661-80-0 2-[2-(4,5-Dimethoxy-2-methyl-phenyl)-ethyl]-isoindole-1,3-dione 
• 31706-88-4 (E)-2-(4,5-Dimethoxy-2-methyl-phenyl)-5-phenyl-pent-4-enenitrile 
• 94823-73-1 4,5-dimethoxy-2-methyl-phenethylamine 

Relevant articles and documents

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists

This report describes the syntheses and structure-activity relationships of 8-(4-methoxyphenyl)pyrazolo-[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF1) receptor antagonists. CRF1 receptor antagonists may be potential anxiolytic or antidepressant drugs. This research culminated in the discovery of analogue 12-3, which is a potent, selective CRF1 antagonist (hCRF1 IC50 ) 4.7 ± 2.0 nM) with weak affinity for the CRF-binding protein and biogenic amine receptors. This compound also has a good pharmacokinetic profile in dogs. Analogue 12-3 is orally effective in two rat models of anxiety: the defensive withdrawal (situational anxiety) model and the elevated plus maze test. Analogue 12-3 has been advanced to clinical trials.

Some nuclear-substituted derivatives of alpha-methyldopa.

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