7537-05-5

Basic information

• Product Name: 1-(CHLOROMETHYL)-4,5-DIMETHOXY-2-METHYLBENZENE
• Synonyms: 1-(CHLOROMETHYL)-4,5-DIMETHOXY-2-METHYLBENZENE
• CAS NO: 7537-05-5
• Molecular Formula: C₁₀H₁₃ClO₂
• Molecular Weight: 200.66
• Mol File: 7537-05-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286.6°C at 760 mmHg
• Flash Point: 107°C
• Appearance: /
• Density: 1.106g/cm³
• Vapor Pressure: 0.0045mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: 1-(CHLOROMETHYL)-4,5-DIMETHOXY-2-METHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(CHLOROMETHYL)-4,5-DIMETHOXY-2-METHYLBENZENE(7537-05-5)
• EPA Substance Registry System: 1-(CHLOROMETHYL)-4,5-DIMETHOXY-2-METHYLBENZENE(7537-05-5)

Safety Data

• Hazardous Substances Data: 7537-05-5(Hazardous Substances Data)

Usage

Chemical structure

Substituted phenyl alkyl compound with a chloromethyl group attached to the first carbon, and two methoxy and one methyl group attached to the benzene ring.

Organic synthesis

Intermediate for the production of pharmaceuticals, agrochemicals, and other specialty chemicals.

Research purposes

Substrate for the synthesis of various derivatives.

Pharmaceutical industry

Due to its unique structure and properties.

Therapeutic uses

Further research and development could explore its potential.

Functional groups

Chloromethyl, methoxy, and methyl groups.

InChI:InChI=1/C10H13ClO2/c1-7-4-9(12-2)10(13-3)5-8(7)6-11/h4-5H,6H2,1-3H3

Upstream product

• 494-99-5 1,2-dimethoxy-4-methylbenzene 
• 107-30-2 chloromethyl methyl ether 
• 20736-28-1 4,5-dimethoxy-2-methylbenzoic acid 
• 90926-82-2 2-Methyl-4,5-dimethoxy-benzylalkohol 

Downstream Products

• 117661-77-5 2-(4,5-Dimethoxy-2-methyl-benzyl)-isoindole-1,3-dione 
• 7537-09-9 4,5-dimethoxy-2-methylbenzyl cyanide 
• 1128-57-0 1,2-dimethoxy-4,5-dimethylbenzene 
• 209911-13-7 3,6-Bis-chloromethyl-4,5-dimethyl-benzene-1,2-diol 
• 209911-11-5 1,4-Bis-chloromethyl-2,3-dimethoxy-5,6-dimethyl-benzene 
• 94823-73-1 4,5-dimethoxy-2-methyl-phenethylamine 
• 117661-80-0 2-[2-(4,5-Dimethoxy-2-methyl-phenyl)-ethyl]-isoindole-1,3-dione 
• 117661-82-2 2-[2-(4,5-Dimethoxy-2-methyl-phenyl)-ethyl]-4,5-dimethoxy-isoindole-1,3-dione 
• 7537-13-5 2-(4,5-Dimethoxy-2-methyl-phenyl)-3-oxo-butyronitrile 

Relevant articles and documents

Total synthesis and biological evaluation of an antifungal tricyclic o-hydroxy-p-quinone methide diterpenoid

A convergent route has been developed to synthesize an antifungal tricyclic o-hydroxy-p-quinone methide diterpenoid and analogues. A Li/naphthalene- mediated reductive alkylation was employed for coupling β-cyclocitral and the corresponding benzyl chloride, while a BBr3-mediated one-pot bis-demethylation and intramolecular Friedel-Crafts alkylation was used to assemble the tricyclic molecular skeleton. The structure-activity relationship of the diterpenoid was assessed on the basis of antiproliferation assays of the natural product and analogues against strains of pathogenic yeasts and filamentous fungi.

PHOTOREACTION OF PHTHALIMIDES POSSESSING AN ORTHO-METHYLPHENYL GROUP IN THEIR N-SIDE CHAIN. SYNTHESIS OF TETRACYCLIC NITROGEN HETEROCYCLES

Upon irradiation phthalimides (5 and 8) possesing o-methylphenyl group in their N-side chain gave mainly the tetracyclic ring systems (9 and 10).It was shown that the photocyclization occurs at ε- or ζ-position across the carbons of the benzene ring (B-ring).