75389-56-9

Basic information

• Product Name: ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate
• Synonyms: ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate
• CAS NO: 75389-56-9
• Molecular Weight: 310.353
• Mol File: 75389-56-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate(75389-56-9)
• EPA Substance Registry System: ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate(75389-56-9)

Safety Data

• Hazardous Substances Data: 75389-56-9(Hazardous Substances Data)

Upstream product

• 28643-53-0 1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one 
• 105-36-2 ethyl bromoacetate 
• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 4981-92-4 1-benzylbenzimidazole 
• 95-54-5 1,2-diamino-benzene 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 27265-99-2 ethyl 2-oxo-11-benzimidazolineacetate 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 

Downstream Products

• 75389-70-7 3-benzyl-2-oxo-1-benzimidazolineacetic acid 

Relevant articles and documents

One-pot synthesis of 7,9-dialkylpurin-8-one analogues: Broad substrate scope

The one-pot and direct synthesis of 7,9-dialkylpurin-8-one analogues with broad substrate scope has been developed. This copper-catalyzed C-H oxidation reaction could avoid multistep synthesis of quaternary ammonium salts and expand the scope of halogenated alkanes. Moreover, benzimidazole derivatives are also applicable in the catalytic system.

Propanoic acid derivatives that inhibit the binding of integrins to their receptors

A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds (I) that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which α4β1 is involved. All substituents are as defined in the application.

Synthesis and aldose reductase inhibitory activity of substituted 2(1H)-benzimidazolone- and oxindole-1-acetic acids

Potent in vitro inhibition of the enzyme aldose reductase (AR) was observed with several members of a series of 3-alkylated 2(1H)-benzimidazolone-1-acetic acids, as well as with analogs from a structurally-related series of oxindole-1-acetic acids with 3-alkyl or 3-alkylidene substituents.Intrinsic activity against AR was, in general, greatest in compounds from the second series, especially with analogs which containalkylidene side chains, with typical IC50 values of 1 μM.However, in streptozotocindiabetic rat model, the best compounds from either series failedto prevent sorbitol accumulation in lens or sciatic nerve to the degree observed with AR inhibitors such as ponalrestat or zopolrestat. aldose reductase / diabetes / 2(1H)-benzimidazolone-1-acetic acid / oxindole-1-acetic acid