75389-70-7

Basic information

• Product Name: 2-(3-benzyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetic acid
• Synonyms: 2-(3-benzyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetic acid
• CAS NO: 75389-70-7
• Molecular Weight: 282.299
• Mol File: 75389-70-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(3-benzyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-benzyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetic acid(75389-70-7)
• EPA Substance Registry System: 2-(3-benzyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetic acid(75389-70-7)

Safety Data

• Hazardous Substances Data: 75389-70-7(Hazardous Substances Data)

Usage

Molecular class

benzimidazole derivative

Biological activities

antiviral, antitumor, and anti-inflammatory properties

Potential pharmaceutical application

drug candidate for the treatment of certain diseases

Chemical structure

2-(3-benzyl-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)acetic acid

Need for further research

to explore its potential therapeutic uses.

Upstream product

• 100-39-0 benzyl bromide 
• 27265-99-2 ethyl 2-oxo-11-benzimidazolineacetate 
• 1227248-64-7 (3-benzyl-2-oxo-2,3-dihydrobenzoimidazol-1-yl)-acetic acid t-butyl ester 
• 95-54-5 1,2-diamino-benzene 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 
• 100-44-7 benzyl chloride 
• 28643-53-0 1,3-dihydro-1-(phenylmethyl)-2H-benzimidazol-2-one 
• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 75389-56-9 ethyl 2-(3-benzyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetate 

Downstream Products

• 75389-84-3 3-benzyl-2-oxo-1-benzimidazolineacetamide 

Relevant articles and documents

DEPROTECTION OF BOC-PROTECTED COMPOUNDS

Organic compounds having t-butyl ester or BOC carbonate protecting groups are effectively deprotected by heating in a fluorinated alcohol solution.

Method for treating neoplasia by exposure to N,N′-substituted benzimidazol-2-ones

A method for inhibiting neoplastic cells and related conditions by exposing them to N,N′-substituted benzimidazol-2-ones.

Synthesis and aldose reductase inhibitory activity of substituted 2(1H)-benzimidazolone- and oxindole-1-acetic acids

Potent in vitro inhibition of the enzyme aldose reductase (AR) was observed with several members of a series of 3-alkylated 2(1H)-benzimidazolone-1-acetic acids, as well as with analogs from a structurally-related series of oxindole-1-acetic acids with 3-alkyl or 3-alkylidene substituents.Intrinsic activity against AR was, in general, greatest in compounds from the second series, especially with analogs which containalkylidene side chains, with typical IC50 values of 1 μM.However, in streptozotocindiabetic rat model, the best compounds from either series failedto prevent sorbitol accumulation in lens or sciatic nerve to the degree observed with AR inhibitors such as ponalrestat or zopolrestat. aldose reductase / diabetes / 2(1H)-benzimidazolone-1-acetic acid / oxindole-1-acetic acid