75597-96-5

Basic information

• Product Name: (2R,3R)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane
• Synonyms: (2R,3R)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane
• CAS NO: 75597-96-5
• Molecular Weight: 418.53
• Mol File: 75597-96-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (2R,3R)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane(75597-96-5)
• EPA Substance Registry System: (2R,3R)-2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane(75597-96-5)

Safety Data

• Hazardous Substances Data: 75597-96-5(Hazardous Substances Data)

Upstream product

• 1369589-16-1 5,5'-((1Z,3Z)-2,3-dimethylbuta-1,3-diene-1,4-diyl)bis(1,2,3-trimethoxybenzene) 
• 1369589-13-8 (Z)-5-(2-iodoprop-1-enyl)-1,2,3-trimethoxybenzene 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 101664-64-6 (E)-1,4-bis(3,4,5-trimethoxyphenyl)-2,3-dimethyl-2-butene 
• 93395-16-5 (3S*,4R*)-3-(3,4,5-trimethoxybenzyl)-4-(3,4,5-trimethoxybenzyl)-4,5-dihydro-2(3H)-furanone 
• 124151-39-9 (7S,8S,8'R)-7-hydroxy-3,4,5,3',4',5'-hexamethoxy-8,8'-neolignan 
• 115495-67-5 (2R*,3S*)-2,3-dihydroxymethyl-1,4-bis-(3,4,5-trimethoxyphenyl)butane 
• 50394-05-3 (7S,8S,7′R,8′R)-3,3′,4,4′,5,5′-hexamethoxy-7,7′,8,8′-lignan 
• 115495-69-7 (2R*,3S*)-2,3-(methylsulfonyloxymethyl)-1,4-bis-(3,4,5-trimethoxyphenyl)butane 
• 101664-65-7 (Z)-1,4-bis(3,4,5-trimethoxyphenyl)-2,3-dimethyl-2-butene 
• 487-11-6 elemicin 
• 186581-53-3 diazomethane 
• 66280-26-0 pre-gomisin 
• 121637-68-1 1-(3,4,5-trimethoxyphenyl)-2-bromopropane 

Downstream Products

• 1379671-31-4 5,5'-(2,3-dimethylbutane-1,4-diyl)bis(4-bromo-1,2,3-trimethoxybenzene) 
• 1379671-32-5 5,5'-(2,3-dimethylbutane-1,4-diyl)bis(4-iodo-1,2,3-trimethoxybenzene) 
• 61281-38-7 (+/-)-deoxyschizandrin 
• 14335-63-8 (1α,2β,3α)-6,7,8-trimethoxy-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene 
• 61281-38-7 (+/-)-1,2,3,10,11,12-hexamethoxy-r-6,t-7-dimethyl-5,6,7,8-tetrahydrodibenzocyclooctene 
• 61281-38-7 (8R,8'R)-deoxyschizandrin 
• 14335-63-8 (1α,2β,3β)-6,7,8-trimethoxy-2,3-dimethyl-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene 
• 156769-17-4 schisandrin A 
• 115495-71-1 (+/-)Deoxyschizandrin 

Relevant articles and documents

A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives

The natural product deoxyschizandrin has been shown to have a wide range of biological activities. In recent years the therapeutic potential of this compound against cancers has attracted significant interest. Herein we describe a concise de novo total synthesis of deoxyschizandrin based around a double organocuprate oxidation strategy. In addition, we present the results of biological studies exploring the ability of deoxyschizandrin and synthetic precursors lacking the medium ring biaryl unit to inhibit the proliferation of a human cancer cell line. These studies led to the identification of a structurally novel agent with in vitro anticancer activity. Copyright

Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists

We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1 x 10-6 M) in this study.

Intramolecular Oxidative Coupling of Aromatic Compounds. VI. An Efficient Synthesis of Some Dibenzocyclooctene Lignans

The 1,4-diaryl-2,3-dimethylbutanes (4) and (5) were readily prepared by reductive coupling of an arylacetone precursor followed by hydrogenation.Intramolecular oxidative coupling (dichlorodicyanobenzoquinone/trifluoroacetic acid) gave dibenzocyclooctene derivatives in good yield. (+/-)-Deoxyschizandrin and the corresponding trans isomer, existing in two distinct conformations, were prepared.