758692-47-6Relevant articles and documents
Efficient and regioselective chromium(0)-catalyzed reaction of 2-substituted furans with diazo compounds: Stereoselective synthesis of (2E,4Z)-2-aryl-hexadienedioic acid diesters
Hahn, Norbert D.,Nieger, Martin,D?tz, Karl Heinz
, p. 2662 - 2673 (2004)
Pentacarbonyl (η2-cis-cyclooctene)chromium(0) (1) catalyzes efficiently reactions of diazo compounds with electron-rich furans. The reaction of 2-methoxyfuran (2) with alkyl α-diazoarylacetate (3a-g) furnishes the (2E,4Z -2-aryl-hexadienedioic
An immunomodulator
-
Paragraph 0130-0133, (2022/01/20)
The present invention discloses an immunomodulator, specifically relates to a class of compounds inhibiting IL-17A and its use as an immunomodulator in the preparation of drugs. The present invention discloses a compound shown in formula I, or a stereoisomer thereof in the preparation of inhibiting IL-17A class of drugs, for clinical screening and / or preparation of drugs associated with IL-17A activity related to the drug provides a new option.
B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes
Guo, Jing,Mandal, Dipendu,Stephan, Douglas W.,Wu, Yile,Zhao, Yunbo
, p. 7758 - 7761 (2021/08/13)
Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These reactions provide N1-alkylated benzotriazoles in good to excellent yields and this protocol is successfully adapted to gram-scale syntheses as well as a derivative with antimicrobial activity.
Azide Radical Initiated Ring Opening of Cyclopropenes Leading to Alkenyl Nitriles and Polycyclic Aromatic Compounds
Muriel, Bastian,Waser, Jerome
supporting information, p. 4075 - 4079 (2021/01/18)
We report herein a radical-mediated amination of cyclopropenes. The transformation proceeds through a cleavage of the three-membered ring after the addition of an azide radical on the strained double bond and leads to tetrasubstituted alkenyl nitrile derivatives upon loss of N2. With 1,2-diaryl substituted cyclopropenes, this methodology could be extended to a one-pot synthesis of highly functionalized polycyclic aromatic compounds (PACs). This transformation allows the synthesis of nitrile-substituted alkenes and aromatic compounds from rapidly accessed cyclopropenes using only commercially available reagents.