75950-75-3

Basic information

• Product Name: 3-(2'-methylphenyl)-(Z)-propenoic acid methyl ester
• Synonyms: 3-(2'-methylphenyl)-(Z)-propenoic acid methyl ester
• CAS NO: 75950-75-3
• Molecular Weight: 176.215
• Mol File: 75950-75-3.mol
• Article Data: 109

Chemical Properties

• CAS DataBase Reference: 3-(2'-methylphenyl)-(Z)-propenoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2'-methylphenyl)-(Z)-propenoic acid methyl ester(75950-75-3)
• EPA Substance Registry System: 3-(2'-methylphenyl)-(Z)-propenoic acid methyl ester(75950-75-3)

Safety Data

• Hazardous Substances Data: 75950-75-3(Hazardous Substances Data)

Upstream product

• 939-57-1 (E)-3-(2-methylphenyl)acrylic acid 
• 77-78-1 dimethyl sulfate 
• 95-46-5 2-methylphenyl bromide 
• 292638-85-8 acrylic acid methyl ester 
• 96-32-2 bromoacetic acid methyl ester 
• 529-20-4 2-methylphenyl aldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 95-53-4 o-toluidine 
• 2093-46-1 2-methylphenyl diazonium tetrafluoroborate 
• 74-88-4 methyl iodide 
• 70625-57-9 2-methyl phenylmethylene propanedionic acid dimethyl ether 
• 615-37-2 ortho-methylphenyl iodide 
• 529-28-2 4-iodoanisol 
• 7515-27-7 3-(2-methylphenyl)prop-2-ynoic acid 

Downstream Products

• 861363-01-1 3-hydroxyamino-3-o-tolyl-propionohydroxamic acid 
• 20850-01-5 3-(2-methylphenyl)-2-propen-1-ol 
• 939-57-1 (E)-3-(2-methylphenyl)acrylic acid 
• 501922-06-1 (E)-3-(2-methylphenyl)-2-propenol 
• 70625-62-6 methyl 2-(bromomethyl)cinnamate 
• 146793-49-9 methyl (E)-3-(2’-(bromomethyl)phenyl)acrylate 
• 36681-31-9 o,o'-Dimethyl-β-truxillsaeuredimethylester 
• 1821802-95-2 2-(o-tolyl)cyclopropane-1-carboxylic acid 
• 1859949-36-2 (2-o-tolyl-cyclopropyl)-carbamic acid tert-butyl ester 
• 244103-25-1 (E)-3-(2-((naphthalen-3-yl)methyl)phenyl)acrylic acid 
• 373380-73-5 3-(2-naphthalen-2-ylmethylphenyl)acrylic acid methyl ester 

Relevant articles and documents

SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING A PSYCHIATRIC DISORDER

The present invention relates to a pharmaceutical composition for treating and/or alleviating a psychiatric disorder comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a pharmaceutical composition for inducing anti-stress, anti-anxiety and/or anti-depressant activities comprising a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient.

N-Heterocyclic Carbene/Carboxylic Acid Co-Catalysis Enables Oxidative Esterification of Demanding Aldehydes/Enals, at Low Catalyst Loading

We report the discovery that simple carboxylic acids, such as benzoic acid, boost the activity of N-heterocyclic carbene (NHC) catalysts in the oxidative esterification of aldehydes. A simple and efficient protocol for the transformation of a wide range of sterically hindered α- and β-substituted aliphatic aldehydes/enals, catalyzed by a novel and readily accessible N-Mes-/N-2,4,6-trichlorophenyl 1,2,4-triazolium salt, and benzoic acid as co-catalyst, was developed. A whole series of α/β-substituted aliphatic aldehydes/enals hitherto not amenable to NHC-catalyzed esterification could be reacted at typical catalyst loadings of 0.02–1.0 mol %. For benzaldehyde, even 0.005 mol % of NHC catalyst proved sufficient: the lowest value ever achieved in NHC catalysis. Preliminary studies point to carboxylic acid-induced acceleration of acyl transfer from azolium enolate intermediates as the mechanistic basis of the observed effect.

Oxoammonium-Mediated Allylsilane–Ether Coupling Reaction

A new C(sp3)?H functionalization reaction consisting of the oxidative α-allylation of allyl- and benzyl- methyl ethers has been developed. The C?C coupling could be carried out under mild conditions thanks to the use of cheap and green oxoammonium salts. The scope of the reaction was studied over 27 examples, considering the nature of the substituents on the two coupling partners.