76088-98-7

Basic information

• Product Name: 7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE
• Synonyms: 7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE;7-Fluoro-quinazoline;2,4(1H,3H)-Quinazolinedione, 7-fluoro-;7-Fluoroquinazoline-2,4-dione;7-fluoroquinazoline-2,4-diol;7-Fluoroquinazoline-2,4(1H,3H);7-fluoro-1H-quinazoline-2,4-dione
• CAS NO: 76088-98-7
• Molecular Formula: C₈H₅FN₂O₂
• Molecular Weight: 180.14
• Mol File: 76088-98-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 246.1°C at 760 mmHg
• Flash Point: 102.6°C
• Appearance: /
• Density: 1.434 g/cm³
• Vapor Pressure: 0.0434mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• PKA: 10.38±0.20(Predicted)
• CAS DataBase Reference: 7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE(76088-98-7)
• EPA Substance Registry System: 7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE(76088-98-7)

Safety Data

• Hazardous Substances Data: 76088-98-7(Hazardous Substances Data)

Usage

General Description

7-Fluoroquinazoline-2,4(1H,3H)-dione is a chemical compound with the molecular formula C8H5FN2O2. It is a quinazoline derivative that contains a fluorine atom. 7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE is used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceuticals and bioactive compounds. It possesses potential biological activities and has been studied for its anti-inflammatory, anti-cancer, and anti-microbial properties. Additionally, 7-fluoroquinazoline-2,4(1H,3H)-dione has shown potential as a starting material for the development of new drugs and therapeutic agents.

InChI:InChI=1/C8H5FN2/c9-7-2-1-6-4-10-5-11-8(6)3-7/h1-5H

Upstream product

• 446-32-2 4-fluoroanthranilic acid 
• 57-13-6 urea 
• 590-28-3 potassium cyanate 
• 124-38-9 carbon dioxide 
• 80517-22-2 2-amino-4-fluorobenzonitrile 

Downstream Products

• 1007308-74-8 C₈H₄FN₃O₄ 
• 174566-15-5 2,4,-dichloro-7-fluoroquinazoline 
• 956101-10-3 2-chloro-7-fluoro-quinazoline 
• 1007308-75-9 C₈H₂Cl₂FN₃O₂ 

Relevant articles and documents

Targeting sars-cov-2 polymerase with new nucleoside analogues

Despite the fact that COVID-19 vaccines are already available on the market, there have not been any effective FDA-approved drugs to treat this disease. There are several already known drugs that through drug repositioning have shown an inhibitory activity against SARS-CoV-2 RNA-dependent RNA polymerase. These drugs are included in the family of nucleoside analogues. In our efforts, we synthesized a group of new nucleoside analogues, which are modified at the sugar moiety that is replaced by a quinazoline entity. Different nucleobase derivatives are used in order to increase the inhibition. Five new nucleoside analogues were evaluated with in vitro assays for targeting polymerase of SARS-CoV-2.

Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation

The heterocyclizations from various methyl (2-nitrobenzoyl)carbamates to substituted quinazoline-2,4(1H,3H)-diones under hydrogenation conditions were investigated in this study. In the presence of p-toluenesulfonic acid monohydrate in methanol, various q

Preparation method of quinazoline diketone derivative

The invention belongs to the technical field of medicine, and especially relates to a preparation method of a quinazoline diketone derivative. The preparation method is friendly to the environment; synthesis requirements are low; and operation method is simple. The preparation method comprises following steps: (1) acetonitrile with excellent dissolvability is taken as a solvent, isocyanic acid is prepared via acidification of potassium isocyanate with 2.0 times equivalent weight, and reaction is carried out for 2h at 50 DEG C; (2) 1.88g PPh3 is dissolved in 15ml of methylbenzene, 0.8ml of ethyl bromoacetate is added, reaction is carried out at room temperature for one night; (3) NaOH is added into an obtained reaction liquid, when alkali adding amount is 4 times equivalent weight, it is shown by LC-MS that cyclization reaction is completed, hydrochloric acid is added so as to adjust pH value to 1, the solvent is recovered via decompression, and the quinazoline diketone derivative is obtained via silica-gel column chromatography separation.