761443-69-0 Usage
Description
1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE is a complex chemical compound featuring a pyrrolopyrazole ring with various substituents, including ethyloxycarbonyl, piperazinyl, and benzyloxy groups. The presence of a BOC (tert-butoxycarbonyl) protecting group further characterizes this molecule. It is a promising drug candidate with potential applications in therapeutics, possibly as an anti-cancer or anti-inflammatory agent. Its intricate structure and functional groups suggest a range of pharmacological activities and biological relevance, making it a significant subject of interest in the fields of medicinal chemistry and drug discovery.
Uses
Used in Pharmaceutical Industry:
1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE is used as a potential drug candidate for its possible anti-cancer or anti-inflammatory properties, due to its complex structure and functional groups that may contribute to its pharmacological activity.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE serves as a subject of interest for its potential to be developed into new therapeutic agents, given its unique molecular structure and the presence of a BOC protecting group that may be relevant to its synthesis and modification for various applications.
Used in Drug Discovery:
1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE is utilized in drug discovery processes to explore its potential as a lead compound for the development of new medications, particularly in areas where its anti-cancer or anti-inflammatory properties could be beneficial.
Check Digit Verification of cas no
The CAS Registry Mumber 761443-69-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,1,4,4 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 761443-69:
(8*7)+(7*6)+(6*1)+(5*4)+(4*4)+(3*3)+(2*6)+(1*9)=170
170 % 10 = 0
So 761443-69-0 is a valid CAS Registry Number.
761443-69-0Relevant articles and documents
(R)- N - [5 - (2 - methoxy - 2 - phenyl-acetyl) - 1, 4, 5, 6 - tetrahydro-pyrrolo [3, 4 - c] pyrazole - 3 - yl] - 4 - (4 - methyl piperazine - 1 - yl) benzamide synthesis method
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, (2017/02/17)
The invention belongs to the technical field of medicine and relates to a preparation method for PHA739358(Danusertib), i.e., (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide. According to the invention, altogether four reaction routes are designed, simple and easily available glycine is used as a raw material, reactions like addition, esterification, amino protection and cyclization are carried out so as to prepare (R)-N-[5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-yl]-4-(4-methyl piperazine-1-yl)benzamide, yield of the route 1, 2 and 4 is more than 25%, respectively, and yield of the route 3 is more than 20%. The preparation method has the advantages of a few reaction steps, simple and convenient post-treatment operation, little time consumption, high yield and low total cost. Thus, a novel method is provided for preparation of the antitumor drug PHA739358.
Potent and selective aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition
Fancelli, Daniele,Berta, Daniela,Bindi, Simona,Cameron, Alexander,Cappella, Paolo,Carpinelli, Patrizia,Catana, Cornel,Forte, Barbara,Giordano, Patrizia,Giorgini, Maria Laura,Mantegani, Sergio,Marsiglio, Aurelio,Meroni, Maurizio,Moll, Juergen,Pittalà, Valeria,Roletto, Fulvia,Severino, Dino,Soncini, Chiara,Storici, Paola,Tonani, Roberto,Varasi, Mario,Vulpetti, Anna,Vianello, Paola
, p. 3080 - 3084 (2007/10/03)
Potent and selective Aurora kinase inhibitors were identified from the combinatorial expansion of the 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole bi-cycle, a novel and versatile scaffold designed to target the ATP pocket of protein kinases. The most potent c