916995-47-6

Basic information

• Product Name: 3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5-(2-phenyl-propionyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester
• Synonyms: 3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5-(2-phenyl-propionyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester
• CAS NO: 916995-47-6
• Molecular Weight: 530.627
• Mol File: 916995-47-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5-(2-phenyl-propionyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5-(2-phenyl-propionyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester(916995-47-6)
• EPA Substance Registry System: 3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5-(2-phenyl-propionyl)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester(916995-47-6)

Safety Data

• Hazardous Substances Data: 916995-47-6(Hazardous Substances Data)

Upstream product

• 25145-43-1 (2S)-2-phenylpropionyl chloride 
• 7782-24-3 (S)-2-Phenylpropionic acid 
• 761443-69-0 5-tert-butyl 1-ethyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate 
• 398495-65-3 3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester 
• 398491-59-3 3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 

Relevant articles and documents

1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a potent aurora kinase inhibitor with a favorable antitumor kinase inhibition profile

The optimization of a series of 5-phenylacetyl 1,4,5,6-tetrahydropyrrolo[3, 4-c]pyrazole derivatives toward the inhibition of Aurora kinases led to the identification of compound 9d. This is a potent inhibitor of Aurora kinases that also shows low nanomol