76350-85-1

Basic information

• Product Name: (2'-METHYLBIPHENYL-3-YL)-METHANOL
• Synonyms: RARECHEM AL BD 1346;(2'-METHYLBIPHENYL-3-YL)-METHANOL;(2'-METHYL[1,1'-BIPHENYL]-3-YL)METHANOL;AKOS BAR-1264;3-(2-Tolyl)benzyl alcohol
• CAS NO: 76350-85-1
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.26
• Product Categories: pharmacetical
• Mol File: 76350-85-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2'-METHYLBIPHENYL-3-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2'-METHYLBIPHENYL-3-YL)-METHANOL(76350-85-1)
• EPA Substance Registry System: (2'-METHYLBIPHENYL-3-YL)-METHANOL(76350-85-1)

Safety Data

• Hazardous Substances Data: 76350-85-1(Hazardous Substances Data)

Usage

General Description

(2'-Methylbiphenyl-3-yl)-methanol, also known as 2-Methyl-3'-hydroxy-1,1'-biphenyl, is a chemical compound with the molecular formula C14H14O. It is a derivative of biphenyl, and its structure consists of a biphenyl core with a methyl group substituted at the 2' position and a hydroxyl group at the 3' position. (2'-METHYLBIPHENYL-3-YL)-METHANOL has potential applications in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds due to its unique structural features. It may also be used as a reagent in organic chemistry reactions or as a building block for the synthesis of more complex organic molecules.

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 208941-39-3 4-(4-Carboxy-butoxy)-benzoic acid 3-iodo-benzyl ester 
• 35005-21-1 4-(4-Carboxy-butoxy)-benzoic acid 
• 95-46-5 2-methylphenyl bromide 
• 87199-15-3 [3-(hydroxymethyl)phenyl]boronic acid 
• 371764-26-0 2'-methyl-(1,1'-biphenyl)-3-carbaldehyde 

Relevant articles and documents

Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold

Based on a previously reported phenoxyacetic acid scaffold, compound 7 (HWL-088) has been identified as a superior free fatty acid receptor 1 (FFA1) agonist by comprehensive structure-activity relationship study. Our results indicated that the introduction of ortho-fluoro greatly increased the activity of phenoxyacetic acid series, and the unique structure-activity relationship in biphenyl moiety is different from previously reported FFA1 agonists. Moreover, the modeling study was also performed to better understand the binding mode of present series. Compound 7 significantly improved glucose tolerance both in normal and diabetic models, and even exerted greater potential on glucose control than that of TAK-875. These findings provided a novel candidate HWL-088, which is currently in preclinical study to evaluate its potential for the treatment of diabetes.

Pd-mediated C-C and C-S bond formation on solid support: A scope and limitations study

The scope and limitations of Pd(0)-mediated coupling reactions between aromatic halides linked to a polystyrene resin and boronic acid derivatives (Suzuki coupling), aromatic and vinylic tin compounds (Stille coupling), as well as thiols are reported. For all reactions, conditions were optimized and evaluated with various reagents. In many cases, upon cleavage from the solid support, products were obtained in excellent yields. In most cases, the optimized reaction conditions are superior to those previously reported in the literature.