76368-10-0Relevant articles and documents
ASYMMETRIC SYNTHESIS OF β-LACTAMS. I. THE REACTION OF DIMETHYLKETENE SILYL ACETAL WITH (S)-ALKYLIDENE(1-ARYLETHYL)AMINES PROMOTED BY TITANIUM TETRACHLORIDE
Ojima, Iwao,Inaba, Shin-ichi
, p. 2077 - 2080 (2007/10/02)
Asymmetric synthesis of β-lactams by means of the reaction of dimethyl-ketene silyl acetal with (S)-alkylidene(1-arylethyl)amines in the presence of titanium tetrachloride was studied.The extent of the asymmetric induction was in the range of 44-78percent (diastereomeric purity 72-89percent) and the (S)-configuration was turned to be preferentially induced at the 4C position of the resulting β-lactams.