76727-24-7

Basic information

• Product Name: 3-(2-FLUORO-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(2-FLUORO-PHENYL)-PROPAN-1-OL;1-Fluoro-2-(3-hydroxypropyl)benzene
• CAS NO: 76727-24-7
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.1814432
• Mol File: 76727-24-7.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 237°C at 760 mmHg
• Flash Point: 118.8°C
• Appearance: /
• Density: 1.097g/cm³
• Vapor Pressure: 0.0251mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• PKA: 14.99±0.10(Predicted)
• CAS DataBase Reference: 3-(2-FLUORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FLUORO-PHENYL)-PROPAN-1-OL(76727-24-7)
• EPA Substance Registry System: 3-(2-FLUORO-PHENYL)-PROPAN-1-OL(76727-24-7)

Safety Data

• Hazardous Substances Data: 76727-24-7(Hazardous Substances Data)

Usage

Description

3-(2-Fluoro-phenyl)-propan-1-ol is a chemical compound with the molecular formula C9H11FO. It is a colorless, slightly viscous liquid that is used in the synthesis of various organic compounds. This chemical is a derivative of propan-1-ol, with an added 2-fluoro-phenyl group attached to the third carbon atom. It is commonly used as a building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It has also been studied for its potential pharmacological properties, including its potential as an analgesic and anti-inflammatory agent. Additionally, it is used as a precursor in the production of flavors and fragrances. Overall, 3-(2-fluoro-phenyl)-propan-1-ol is an important and versatile compound in the field of organic chemistry with various industrial and research applications.

Uses

Used in Pharmaceutical Industry:
3-(2-Fluoro-phenyl)-propan-1-ol is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical structure and potential pharmacological properties.
Used in Agrochemical Industry:
3-(2-Fluoro-phenyl)-propan-1-ol is used as a precursor in the production of agrochemicals, contributing to the development of effective and targeted pest control solutions.
Used in Fine Chemicals Industry:
3-(2-Fluoro-phenyl)-propan-1-ol is utilized as a key intermediate in the synthesis of various fine chemicals, enhancing the performance and functionality of these specialty products.
Used in Flavors and Fragrances Industry:
3-(2-Fluoro-phenyl)-propan-1-ol is used as a precursor in the production of flavors and fragrances, adding unique and desirable scents to a wide range of consumer products.
Used in Research and Development:
3-(2-Fluoro-phenyl)-propan-1-ol is employed in research settings for the exploration of its potential as an analgesic and anti-inflammatory agent, as well as for the development of new organic compounds and materials.

InChI:InChI=1/C9H11FO/c10-9-6-2-1-4-8(9)5-3-7-11/h1-2,4,6,11H,3,5,7H2

Upstream product

• 39856-89-8 ethyl 3-(2-fluorophenyl)propionate 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 
• 143654-59-5 methyl 3-(2-fluorophenyl)propanoate 
• 446-52-6 2-Fluorobenzaldehyde 
• 104201-65-2 methyl (2E)-3-(2-fluorophenyl)prop-2-enoate 
• 18944-77-9 2-fluorocinnamic acid 
• 348-13-0 ethyl 3-(2-fluorophenyl)propenoate 
• 451-69-4 2-fluorocinnamic acid 
• 766-49-4 (2-fluorophenyl)acetylene 
• 877149-83-2 3-(2-fluorophenyl)propanenitrile 
• 50919-06-7 2-(2-fluorophenyl)ethanol 
• 130680-89-6 2-fluorobenzeneethanol methanesulfonate (ester) 

Downstream Products

• 166949-93-5 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene 
• 129254-75-7 1-bromo-3-(2-fluorophenyl)-propane 
• 496-11-7 INDANE 
• 6134-53-8 4-bromo-2,3-dihydro-1H-indene 
• 201486-99-9 (+/-)-Hydroxy-phenyl-(indanyl-⁽⁴⁾)-methan 
• 912551-99-6 1-fluoro-2-propylbenzene 
• 201486-97-7 2-fluoro-1-(3-iodopropyl)benzene 
• 1355088-70-8 C₂₁H₂₁FO₂ 
• 175143-93-8 3-(2-fluorophenyl)propanal 
• 1394046-56-0 (R)-2-(2-fluorobenzyl)-5-oxohexanal 
• 1394046-36-6 (R)-4-(2-fluorobenzyl)cyclohex-2-enone 
• 110406-96-7 3-(2-fluorophenoxy)propyl chloride 
• 213617-46-0 C₉H₇FO 

Relevant articles and documents

NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME

A compound selectively inhibiting Nav1.7 over Nav1.5 is provided. A heteroaromatic amide derivative or salt thereof showing high efficacy for various diseases associated with Nav1.7 such as pain, represented by the general formula (I) [wherein, X1-X2 is N-C or C-N, Y1 , Y2, Y3 and Y4 are -CH2-, -CR4aH- or -O- and so on, Z1 is-O- and so on, ring A is a 3- to 7-membered monocyclic aromatic ring and so on, R1a and R1b are a hydrogen atom or a halogen atom and so on, R2 is a hydrogen atom and so on, R3a, R3b and R3c are a hydrogen atom or an optionally substituted C1-C6 haloalkyl group and so on, R4a, R4b and R4c are, an optionally substituted C1-C6 haloalkyl group or C1-C6 haloalkoxy group and so on, R5a is a hydrogen atom and so on, R5a and R5b together form -CH2O- and so on, R6a and R6b are a hydrogen atom and so on, n is 1 or 2.].

Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination

We report both an intermolecular C-H amination of arenes to access N-methylanilines and an intramolecular variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions.

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).