39856-89-8

Basic information

• Product Name: 3-(2-FLUORO-PHENYL)-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(2-FLUORO-PHENYL)-PROPIONIC ACID ETHYL ESTER;Benzenepropanoic acid, 2-fluoro-, ethyl ester;ethyl 3-(2-fluorophenyl)propanoate
• CAS NO: 39856-89-8
• Molecular Formula: C₁₁H₁₃FO₂
• Molecular Weight: 196.22
• Mol File: 39856-89-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 247.523°C at 760 mmHg
• Flash Point: 100.536°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 0.026mmHg at 25°C
• Refractive Index: 1.485
• CAS DataBase Reference: 3-(2-FLUORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FLUORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(39856-89-8)
• EPA Substance Registry System: 3-(2-FLUORO-PHENYL)-PROPIONIC ACID ETHYL ESTER(39856-89-8)

Safety Data

• Hazardous Substances Data: 39856-89-8(Hazardous Substances Data)

Usage

Description

3-(2-Fluoro-phenyl)-propionic acid ethyl ester, also known as flurbiprofen ethyl ester, is a chemical compound derived from the nonsteroidal anti-inflammatory drug (NSAID) flurbiprofen. It is considered a prodrug form of the active compound, with potential for improved bioavailability and effectiveness. This ester form possesses anti-inflammatory, analgesic, and antipyretic properties, positioning it as a promising candidate for the development of new drugs in the pharmaceutical and medicinal industries for pain and inflammation management.

Uses

Used in Pharmaceutical Industry:
3-(2-Fluoro-phenyl)-propionic acid ethyl ester is used as a prodrug for flurbiprofen, an NSAID, for its potential to improve bioavailability and effectiveness. It is being studied for its potential applications in pain and inflammation management.
Used in Medicinal Industry:
3-(2-Fluoro-phenyl)-propionic acid ethyl ester is used as a pharmaceutical compound with anti-inflammatory, analgesic, and antipyretic properties, making it a promising candidate for the development of new drugs to manage pain and inflammation.

InChI:InChI=1/C11H13FO2/c1-2-14-11(13)8-7-9-5-3-4-6-10(9)12/h3-6H,2,7-8H2,1H3

Upstream product

• 348-13-0 ethyl 3-(2-fluorophenyl)propenoate 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 451-69-4 2-fluorocinnamic acid 
• 18944-77-9 2-fluorocinnamic acid 
• 89760-42-9 (2E)-3-(2-fluorophenyl)prop-2-enoic acid ethyl ester 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 
• 75-03-6 ethyl iodide 
• 877149-83-2 3-(2-fluorophenyl)propanenitrile 
• 50919-06-7 2-(2-fluorophenyl)ethanol 
• 130680-89-6 2-fluorobenzeneethanol methanesulfonate (ester) 
• 446-52-6 2-Fluorobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 76727-24-7 3-(2-fluorophenyl)propan-1-ol 
• 168285-26-5 5-(2-Fluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 168285-09-4 5-(2-Fluoro-benzyl)-1H-pyrimidine-2,4-dione 
• 1026812-11-2 Acetic acid 2-[5-(2-fluoro-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester 
• 449811-16-9 6-(2-fluorobenzyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1643-26-1 3-(2-fluorophenyl)propionic acid 
• 449808-56-4 6-(2-fluorobenzyl)-8-methyl-2-methylsulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 790652-90-3 6-(2-fluorobenzyl)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 
• 110406-96-7 3-(2-fluorophenoxy)propyl chloride 

Relevant articles and documents

REACTIONS OF COORDINATED LIGANDS. IX. CHROMIUM(O)-PROMOTED INTRAMOLECULAR NUCLEOPHILIC SUBSTITUTION OF AN ARYL HALIDE: A PREPARATION OF CHROMAN

When treated with potassium t-butoxide in dimethyl sulphoxide the chromium tricarbonyl complex of 3-(2-fluorophenyl)propan-1-ol underwent a rapid intramolecular nucleophilic substitution to give the corresponding complex of chroman, from which the heteroc

NOVEL PHARMACEUTICAL COMPRISING HETEROAROMATIC AMIDE DERIVATIVE OR SALT THEREOF

PROBLEM TO BE SOLVED: To provide a compound useful for treating or preventing disease associated with voltage-dependent sodium channel (Nav1.7) such as disease involving a pain, disease involving an itch, autonomic nerve-associated disease, or a pharmaceutical composition thereof. SOLUTION: The present disclosure provides a compound illustrated by the following formula, and a pharmaceutical composition containing the same. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl) propylamino]-8-methyl-8 H -pyrido[2,3- d ]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2 H -pyran-4-ylamino)pyrido[2,3- d ]pyrimidin-7(8 H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase

The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study for rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.