76937-64-9

Basic information

• Product Name: 1-(4-Benzyloxy-2-methoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione
• CAS NO: 76937-64-9
• Molecular Weight: 466.533
• Mol File: 76937-64-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-Benzyloxy-2-methoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Benzyloxy-2-methoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione(76937-64-9)
• EPA Substance Registry System: 1-(4-Benzyloxy-2-methoxy-phenyl)-3-(4-benzyloxy-phenyl)-propane-1,3-dione(76937-64-9)

Safety Data

• Hazardous Substances Data: 76937-64-9(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 5427-29-2 methyl 2-hydroxy-4-benzyloxybenzoate 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 54696-05-8 4'-benzyloxy-acetophenone 
• 28478-45-7 methyl 4-benzyloxy-2-methoxybenzoate 

Downstream Products

• 75808-78-5 2'-O-methyl-licodione 

Relevant articles and documents

BIOSYNTHESIS OF A RETROCHALCONE ECHINATIN: INVOLVEMENT OF O-METHYLTRANSFERASE TO LICODIONE

In order to clarify the O-methylation step in the bisynthesis of a retrochalcone, echinatin (4,4'-dihydroxy-2-methoxychalcone), methyl transfer from S-adenosyl-L-methionine (SAM) to licodione (1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione) in the cell-free extract of the cultured cells of Glycyrrhiza echinata was examined.Time course of methyl transferring activity during culture cycle in 4 strains was correlated to echinatin content.The enzyme catalysing this reaction, licodione O-methyltransferase (LMT), was purified 135-fold.Substrate specificity studies implied that the hydroxy group ortho to the C3 linkage in licodione was methylated in this reaction.O-Methyl-licodiones were synthesized for comparison and the sole product of LMT-catalysed reaction was identified as 2'-O-methyl-licodione.A possible scheme for the last steps of echinatin biosynthesis is proposed. - Key Word Index: Glycyrrhiza echinata; Leguminosae; cell culture; cell free extract; retrochalcone biosynthesis; enzyme; O-methyltransferase; echinatin; licodione; O-methyl-licodiones.