77055-43-7 Usage
Description
(4-ISOTHIOCYANATO-PHENYL)-ACETIC ACID METHYL ESTER, with the molecular formula C10H9NOS2, is an ester derivative of (4-isothiocyanato-phenyl)-acetic acid featuring a methyl group attached to the carboxyl group. This chemical compound is widely utilized in organic synthesis and medicinal chemistry, serving as a fundamental building block for the creation of various pharmaceutical compounds. Recognized for its potential as an anti-cancer agent, it has been the subject of research for its anticancer and antiproliferative properties. Furthermore, it has been investigated for its possible antimicrobial and antioxidant activities, establishing its significance in pharmaceutical research and development.
Uses
Used in Pharmaceutical Research and Development:
(4-ISOTHIOCYANATO-PHENYL)-ACETIC ACID METHYL ESTER is used as a building block for the synthesis of pharmaceutical compounds due to its versatile chemical structure and potential applications in medicinal chemistry.
Used in Anticancer Applications:
In the field of oncology, (4-ISOTHIOCYANATO-PHENYL)-ACETIC ACID METHYL ESTER is used as a potential anti-cancer agent for its studied anticancer and antiproliferative properties, offering promise in the development of novel treatments for various types of cancer.
Used in Antimicrobial Applications:
(4-ISOTHIOCYANATO-PHENYL)-ACETIC ACID METHYL ESTER is also used as a potential antimicrobial agent, given its explored properties that may contribute to the development of new antimicrobial drugs to combat resistant bacteria and other pathogens.
Used in Antioxidant Applications:
Additionally, (4-ISOTHIOCYANATO-PHENYL)-ACETIC ACID METHYL ESTER is used as a potential antioxidant agent, with its antioxidant activities being investigated for possible applications in the development of compounds that can protect against oxidative stress and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 77055-43-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,0,5 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 77055-43:
(7*7)+(6*7)+(5*0)+(4*5)+(3*5)+(2*4)+(1*3)=137
137 % 10 = 7
So 77055-43-7 is a valid CAS Registry Number.
77055-43-7Relevant articles and documents
Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase
Goodyer, Claire L. M.,Chinje, Edwin C.,Jaffar, Mohammed,Stratford, Ian J.,Threadgill, Michael D.
, p. 4189 - 4206 (2007/10/03)
Inhibition of the isoforms of nitric oxide synthase (NOS) has important applications in therapy of several diseases, including cancer. Using 1400W [N-(3-aminomethylbenzyl)acetamidine], thiocitrulline and N δ-(4,5-dihydrothiazol-2-yl)ornithine as lead compounds, series of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas were designed as inhibitors of NOS. Ring-substituted benzyl and phenyl isothiocyanates were synthesised by condensation of the corresponding amines with thiophosgene and addition of ammonia gave the corresponding thioureas in high yields. The substituted 2-amino-4,5-dihydrothiazoles were approached by two routes. Treatment of simple benzylamines with 2-methylthio-4,5-dihydrothiazole at 180 °C afforded the corresponding 2-benzylamino-4,5-dihydrothiazoles. For less nucleophilic amines and those carrying more thermally labile substituents, the 4,5-dihydrothiazoles were approached by acid-catalysed cyclisation of N-(2-hydroxyethyl)thioureas. This cyclisation was shown to proceed by an SN2-like process. Modest inhibitory activity was shown by most of the thioureas and 4,5-dihydrothiazoles, with N-(3-aminomethylphenyl)thiourea (IC50=13 μM vs rat neuronal NOS and IC50=23 μM vs rat inducible NOS) and 2-(3-aminomethylphenylamino)-4,5-dihydrothiazole (IC50=13 μM vs rat neuronal NOS and IC50=19 μM vs human inducible NOS) being the most potent. Several thioureas and 4,5-dihydrothiazoles were found to stimulate the activity of human inducible NOS in a time-dependent manner.
