771582-26-4

Basic information

• Product Name: 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE
• Synonyms: RARECHEM AL BW 1029;2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE;1-[2-Bromo-5-(trifluoromethyl)phenyl]methanamine;(2-bromo-5-(trifluoromethyl)phenyl)methanamine
• CAS NO: 771582-26-4
• Molecular Formula: C₈H₇BrF₃N
• Molecular Weight: 254.05
• Mol File: 771582-26-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE(771582-26-4)
• EPA Substance Registry System: 2-BROMO-5-TRIFLUOROMETHYL-BENZYLAMINE(771582-26-4)

Safety Data

• Hazardous Substances Data: 771582-26-4(Hazardous Substances Data)

Upstream product

• 1483-55-2 2-bromo-5-trifluoromethylbenzonitrile 
• 102684-91-3 2-bromo-5-(trifluoromethyl)benzaldehyde 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 1365840-89-6 tert-butyl N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}-carbamate 
• 1365840-90-9 tert-butyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)-phenyl]methyl}carbamate 
• 1365840-91-0 tris(propan-2-yl)silyl N-benzyl-N-{[2-ethenyl-5-(trifluoromethyl)phenyl]methyl}carbamate 
• 1365840-92-1 tris(propan-2-yl)silyl N-benzyl-N-{[2-formyl-5-(trifluoromethyl)phenyl]methyl}carbamate 
• 1365841-23-1 (6R,7R)-8-benzyl-6-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}-12-(trifluoromethyl)-5-oxa-8-azatricyclo-[8.4.0.0^3,7]tetradeca-1⁽¹⁴⁾,2,10,12-tetraen-4-one 
• 1365841-33-3 [(3R)-2-benzyl-3-(hydroxymethyl)-8-(trifluoromethyl)-2,3-di-hydro-1H-2-benzaze-pin-4-yl]methanol 
• 1365840-88-5 tert-butyl N-{[2-bromo-5-(trifluoromethyl)phenyl]methyl}-carbamate 
• 1420069-44-8 3-[2-[(3-cyclopropyl-5-methyl-4H-1,2,4-triazol-4-yl)methyl]-4-(trifluoromethyl)phenyl]-5-fluoro-1H-indole 
• 1420068-53-6 N-[2-bromo-5-(trifluoromethyl)benzyl]cyclopropanecarbothioamide 
• 1420068-54-7 4-[2-bromo-5-(trifluoromethyl)benzyl]-3-cyclopropyl-5-methyl-4H-1,2,4-triazole 
• 1420068-55-8 3-cyclopropyl-4-[2-[(Z)-2-ethoxyvinyl]-5-(trifluoromethyl)benzyl]-5-methyl-4H-1,2,4-triazole 
• 1420068-52-5 N-[2-bromo-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide 

Relevant articles and documents

IMIDAZOPYRIMIDINES AS EED INHIBITORS AND THE USE THEREOF

The present disclosure provides compounds represented by Formula (I) wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula (I) are FED inhibitors. FED inhibitors are useful for the treatment of cancer and other diseases.

NEW CRTh2 ANTAGONISTS

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Formation of optically pure cyclic amines by intramolecular conjugate displacement

Intramolecular conjugate displacement (ICD) has been applied to the Morita-Baylis-Hillman adducts formed from (5S)-5-(l-menthyloxy)-2(5H)-furanone and aldehydes that carry a protected β- or γ-amino group. DIBAL-H reduction of the resulting ICD products releases optically pure six- or seven-membered cyclic amines having a stereogenic center α to nitrogen.