77206-97-4

Basic information

• Product Name: 5-FLUORO-2-NITROBENZAMIDE
• Synonyms: 5-FLUORO-2-NITROBENZAMIDE
• CAS NO: 77206-97-4
• Molecular Formula: C₇H₅FN₂O₃
• Molecular Weight: 184.126
• Mol File: 77206-97-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-FLUORO-2-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-NITROBENZAMIDE(77206-97-4)
• EPA Substance Registry System: 5-FLUORO-2-NITROBENZAMIDE(77206-97-4)

Safety Data

• Hazardous Substances Data: 77206-97-4(Hazardous Substances Data)

Upstream product

• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 455-38-9 3-fluorobenzoic acid 

Downstream Products

• 421558-77-2 2-nitro-5-(piperidin-1-yl)benzamide 
• 870104-61-3 2,2,2-trifluoro-N-[2-[4-[[3-(aminocarbonyl)-4-nitrophenyl]thio]phenyl]ethyl]acetamide 
• 56339-37-8 5-[(2-chloro-α,α,α-trifluoro-p-tolyl)oxy]-2-nitrobenzamide 
• 50594-78-0 5-fluoro-2-nitrobenzonitrile 
• 63069-49-8 2-amino-5-fluorobenzamide 
• 1034975-02-4 5-benzenesulfonyl-2-nitro-benzamide 
• 383148-04-7 5-(4-methylpiperazin-1-yl)-2-nitrobenzamide 
• 371945-79-8 6-fluoro-2-phenyl-3H,4H-quinazolin-4-one 
• 1241234-79-6 6-fluoro-2-(3-fluorophenyl)-4-quinazolinone 
• 885277-09-8 C₁₄H₈ClFN₂ 
• 1272776-34-7 C₁₄H₇ClF₂N₂ 
• 1304764-83-7 4-anilino-6-fluoro-2-phenylquinazoline 
• 1304764-85-9 4-anilino-6-fluoro-2-(3-fluorophenyl)quinazoline 
• 1304764-87-1 6-fluoro-2-(3-fluorophenyl)-4-(4-methoxyanilino)quinazoline 

Relevant articles and documents

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)

Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-substituted quinazolinone 26. Structure-activity relationship (SAR) studies indicated a crucial role for both meta-nitro substituents for antitubercular activity, while the introduction of polar substituents on the quinazolinone core allowed reduction of bovine serum albumin (BSA) binding (63c, 63d). While most of the tested quinazolinones exhibited no cytotoxicity against MRC-5, the most potent compound 26 was found to be mutagenic via the Ames test. This analogue exhibited moderate inhibitory potency against Mycobacterium tuberculosis thymidylate kinase, the target of the 3-cyanopyridones that lies at the basis of the current analogues, indicating that the whole-cell antimycobacterial activity of the present S-substituted thioquinazolinones is likely due to modulation of alternative or additional targets. Diminished antimycobacterial activity was observed against mutants affected in cofactor F420 biosynthesis (fbiC), cofactor reduction (fgd), or deazaflavin-dependent nitroreductase activity (rv3547), indicating that reductive activation of the 3,5-dinitrobenzyl analogues is key to antimycobacterial activity.

TETRAHYDROISOQUINOLIN-2-YL-(QUINAZOLIN-4-YL) METHANONE COMPOUNDS AS CANCER CELL GROWTH INHIBITORS

Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.

HOMOGENEOUS TIME RESOLVED FLUORESCENCE BASED TEST SYSTEM

The present invention concerns a fluorescence resonance energy transfer based high throughput test system to measure the formation of the HIV gp41 six-helix bundle. In a first embodiment the current invention relates to a homogeneous time resolved fluorescence-based test system comprising a first helical polypeptide consisting essentially of the sequence of IQN36 (SEQ ID NO:1); a second helical polypeptide consisting essentially of the sequence of C34 (SEQ ID NO: 2) wherein said IQN36 is labeled with a light emitting fluorophore and said C34 is labeled with an ultra-violet excitable fluorophore.