421558-77-2

Basic information

• Product Name: 2-Nitro-5-(piperidin-1-yl)benzaMide
• Synonyms: 2-Nitro-5-(piperidin-1-yl)benzaMide
• CAS NO: 421558-77-2
• Molecular Formula: C₁₂H₁₅N₃O₃
• Molecular Weight: 249.2658
• Mol File: 421558-77-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Nitro-5-(piperidin-1-yl)benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro-5-(piperidin-1-yl)benzaMide(421558-77-2)
• EPA Substance Registry System: 2-Nitro-5-(piperidin-1-yl)benzaMide(421558-77-2)

Safety Data

• Hazardous Substances Data: 421558-77-2(Hazardous Substances Data)

Usage

General Description

2-Nitro-5-(piperidin-1-yl)benzamide is a chemical compound with the molecular formula C14H17N3O3. It is a nitroaromatic compound that contains a piperidine ring. 2-Nitro-5-(piperidin-1-yl)benzamide is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has been found to exhibit antitumor and anti-inflammatory activities, and has potential applications in the development of new medications. 2-Nitro-5-(piperidin-1-yl)benzaMide is known for its reactivity and is susceptible to nitrosylation, reduction, and nitro-group displacement reactions. Overall, 2-Nitro-5-(piperidin-1-yl)benzamide is an important chemical for the pharmaceutical and chemical industries due to its versatile applications and potential therapeutic properties.

Upstream product

• 110-89-4 piperidine 
• 40763-96-0 2-nitro-5-chlorobenzamide 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 77206-97-4 2-nitro-5-fluorobenzamide 
• 455-38-9 3-fluorobenzoic acid 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 

Downstream Products

• 314768-97-3 2-amino-5-(piperidin-1-yl)benzamide 

Relevant articles and documents

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)

Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-substituted quinazolinone 26. Structure-activity relationship (SAR) studies indicated a crucial role for both meta-nitro substituents for antitubercular activity, while the introduction of polar substituents on the quinazolinone core allowed reduction of bovine serum albumin (BSA) binding (63c, 63d). While most of the tested quinazolinones exhibited no cytotoxicity against MRC-5, the most potent compound 26 was found to be mutagenic via the Ames test. This analogue exhibited moderate inhibitory potency against Mycobacterium tuberculosis thymidylate kinase, the target of the 3-cyanopyridones that lies at the basis of the current analogues, indicating that the whole-cell antimycobacterial activity of the present S-substituted thioquinazolinones is likely due to modulation of alternative or additional targets. Diminished antimycobacterial activity was observed against mutants affected in cofactor F420 biosynthesis (fbiC), cofactor reduction (fgd), or deazaflavin-dependent nitroreductase activity (rv3547), indicating that reductive activation of the 3,5-dinitrobenzyl analogues is key to antimycobacterial activity.

2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions

Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: wherein Ar represents R5, R6, R7, R8, R1′, R2′, R3′, R4

Synthesis and preliminary cytotoxic and antifungal evaluation of some 6-N,N-dialkyl 2-aryl-4(3H)-quinazolinone derivatives

Some new 2-aryl-4-quinazolinone derivatives bearing a cyclic amino group at position 6 were prepared and their preliminary cytotoxic and antifungal evaluation is reported. They all showed a moderate cytotoxicity suggesting that not only the oxidation stat