314768-97-3Relevant articles and documents
Synthesis and preliminary cytotoxic and antifungal evaluation of some 6-N,N-dialkyl 2-aryl-4(3H)-quinazolinone derivatives
Lopez, Simon E.,Rosales, Monica E.,Canelon, Carlos E.,Valverde, Edgar A.,Narvaez, Rosa C.,Charris, Jaime E.,Giannini, Fernando A.,Enriz, Ricardo D.,Carrasco, Mirta,Zacchino, Susana
, p. 473 - 480 (2001)
Some new 2-aryl-4-quinazolinone derivatives bearing a cyclic amino group at position 6 were prepared and their preliminary cytotoxic and antifungal evaluation is reported. They all showed a moderate cytotoxicity suggesting that not only the oxidation stat
Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents
Hour,Lee,Chen,Lee,Zhao,Lee
, p. 1574 - 1586 (2013/08/23)
Background and Purpose Our previous study demonstrated that 6-(pyrrolidin-1-yl)-2-(3-methoxyphenyl)quinazolin-4-one (HMJ38) was a potent anti-tubulin agent. Here, HMJ38 was used as a lead compound to develop more potent anti-cancer agents and to examine t
INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS
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Page 177, (2008/06/13)
The present invention provides compounds of formula (I): These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.