77256-62-3

Basic information

• Product Name: 1'-methylbenzyl 2,4,6-triisopropylbenzoate
• Synonyms: 1'-methylbenzyl 2,4,6-triisopropylbenzoate
• CAS NO: 77256-62-3
• Molecular Weight: 352.517
• Mol File: 77256-62-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1'-methylbenzyl 2,4,6-triisopropylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-methylbenzyl 2,4,6-triisopropylbenzoate(77256-62-3)
• EPA Substance Registry System: 1'-methylbenzyl 2,4,6-triisopropylbenzoate(77256-62-3)

Safety Data

• Hazardous Substances Data: 77256-62-3(Hazardous Substances Data)

Upstream product

• 98-85-1 1-Phenylethanol 
• 49623-71-4 2,4,6-triisopropylbenzoic acid 
• 100-41-4 ethylbenzene 
• 57199-00-5 2,4,6-triisopropylbenzoyl chloride 
• 21524-34-5 2,4,6-triisopropyl-1-bromobenzene 
• 77256-41-8 benzyl 2,4,6-triisopropylbenzoate 
• 74-88-4 methyl iodide 

Downstream Products

• 77256-83-8 2-(2-phenylpropyl) 2,4,6-triisopropylbenzoate 
• 173031-59-9 Methyl 2-phenyl-2-(2,4,6-triisopropylbenzyloxy)propionate 
• 173031-63-5 2-Phenyl-2-(2,4,6-triisopropylbenzoyloxy)-1-propanol 
• 2406-22-6 (R)-1-phenyl-1,2-ethanediol 
• 2406-22-6 (2S)-2-phenylpropane-1,2-diol 
• 4217-66-7 1,2-dihydroxy-2-phenylpropane 

Relevant articles and documents

The two alternative rate-determining steps in benzylic lithiation reactions of esters and Carbamates

Lithiation reactions of tertiary benzylic esters and carbamates have been studied. Kinetic methodology revealed that a two-step reaction pathway should be considered for these reactions, where either the lithium precomplexation and/or the proton transfer

Chiral Carbanions, 1. - Configurational Stability and Reactions of α-Acyloxy-Substituted α-Methylbenzyllithium Compounds

Racemic and optically active 1-phenylethyl esters of pivalic, (-)-camphanic and 2,4,6-triisopropylbenzoic acid were prepared.The esters 7a of pivalic acid were deprotonated with lithium 2,2,6,6-tetramethylpiperidide (Li-TMP) to form α-oxy-α-methylbenzyllithium compounds which are partly configurationally stable prior to acylation with starting material.Camphanic ester (-)-7b cannot be deprotonated by Li-TMP and t-BuLi is added to the ester function to afford ketone (-)-12a. 1-Phenylethyl 2,4,6-triisopropylbenzoates 16 were transformed within minutes to carbanions 19 by using s-BuLi/TMEDA in THF, hexane, toluene and s-BuLi without TMEDA in toluene/20percent diethyl ether at -78 deg C.The carbanions are configurationally stable only in toluene/20percent diethyl ether and racemise partly in the other solvents.They react with a variety of electrophiles with either retention or inversion (Me3SnCl) of configuration.Carbanions 19 rearrange on warming to -20 deg C to hydroxy ketone 24 with racemisation. - Keywords: Esters, 1-phenylethyl; Carbanions, α-methyl-α-oxybenzyl, configurational stability; Ester-hydroxy ketone rearrangement