7731-10-4

Basic information

• Product Name: apiolic acid
• Synonyms: apiolic acid;4,7-Dimethoxy-1,3-benzodioxole-5-carboxylic acid;Apiole acid
• CAS NO: 7731-10-4
• Molecular Formula: C₁₀H₁₀O₆
• Molecular Weight: 226.18
• Mol File: 7731-10-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: apiolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: apiolic acid(7731-10-4)
• EPA Substance Registry System: apiolic acid(7731-10-4)

Safety Data

• Hazardous Substances Data: 7731-10-4(Hazardous Substances Data)

Upstream product

• 523-80-8 apiol 
• 17672-88-7 isoapiol 
• 4720-78-9 4,7-dihydroxy-benzo[1,3]dioxole-5-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 4776-00-5 4-hydroxybenzo[d][1,3]dioxole-5-carboxylic acid 
• 610-02-6 2,3,4-trihydroxybenzoic acid 
• 17055-09-3 4,7-dimethoxy-benzo[1,3]dioxole-5-carbaldehyde 
• 484-52-6 isoapiole 

Downstream Products

• 109765-60-8 2,3-dihydroxy-1,4-dimethoxybenzene 
• 858836-25-6 3,4-dihydroxy-2,5-dimethoxy-benzoic acid 
• 1293408-37-3 C₂₃H₃₀O₇Si 
• 1293408-42-0 (3-hydroxy-4-methoxyphenyl)(2,5-dimethoxy-3,4-methylenedioxyphenyl)methanone 
• 1240173-91-4 2-(4-methoxyphenyl)-3-oxo-3-(2,5-dimethoxy-3,4-methylenedioxyphenyl)propanenitrile 
• 1449420-92-1 4-(4-methoxyphenyl)-5-(2,5-dimethoxy-3,4-methylenedioxyphenyl)-1H-pyrazol-3-amine 

Relevant articles and documents

Reprint of: Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues

Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.

Cis -restricted 3-aminopyrazole analogues of combretastatins: Synthesis from plant polyalkoxybenzenes and biological evaluation in the cytotoxicity and phenotypic sea urchin embryo assays

We have synthesized a series of novel cis-restricted 4,5-polyalkoxydiaryl- 3-aminopyrazole analogues of combretastatins via short synthetic sequences using building blocks isolated from dill and parsley seed extracts. The resulting compounds were tested in vivo in the phenotypic sea urchin embryo assay to reveal their antimitotic and antitubulin effects. The most potent aminopyrazole, 14a, altered embryonic cell division at 10 nM concentration, exhibiting microtubule-destabilizing properties. Compounds 12a and 14a displayed pronounced cytotoxicity in the NCI60 anticancer drug screen, with the ability to inhibit growth of multi-drug-resistant cancer cells.

Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes (1)

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