77341-09-4

Basic information

• Product Name: 3-triMethylsilyloxy-7-ketolithocholic Methyl ester
• Synonyms: 3-triMethylsilyloxy-7-ketolithocholic Methyl ester;Obeticholic Acid Intermediate
• CAS NO: 77341-09-4
• Molecular Formula: C₂₈H₄₈O₄Si
• Molecular Weight: 492.76322
• EINECS: -0
• Mol File: 77341-09-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-triMethylsilyloxy-7-ketolithocholic Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-triMethylsilyloxy-7-ketolithocholic Methyl ester(77341-09-4)
• EPA Substance Registry System: 3-triMethylsilyloxy-7-ketolithocholic Methyl ester(77341-09-4)

Safety Data

• Hazardous Substances Data: 77341-09-4(Hazardous Substances Data)

Usage

Description

3-triMethylsilyloxy-7-ketolithocholic Methyl ester is a chemical compound derived from lithocholic acid, a bile acid found in the body. It is characterized by the presence of a trimethylsilyloxy group at the 3-position and a ketone group at the 7-position, as well as a methyl ester group. 3-triMethylsilyloxy-7-ketolithocholic Methyl ester is used as a reactant in the synthesis of Obeticholic Acid, a drug used for the treatment of primary biliary cirrhosis and other liver diseases.

Uses

Used in Pharmaceutical Industry:
3-triMethylsilyloxy-7-ketolithocholic Methyl ester is used as a reactant in the preparation of Obeticholic Acid for the treatment of primary biliary cirrhosis and other liver diseases. Its unique chemical structure allows for the synthesis of Obeticholic Acid, which has therapeutic effects on liver function and overall health.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 10538-59-7 7-ketolithocholic methyl ester 
• 4651-67-6 7-Ketolithocholic acid 
• 474-25-9 chenodeoxycholic acid 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 

Downstream Products

• 915038-24-3 (E/Z)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid 
• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 

Relevant articles and documents

Crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid as well as preparation method and application of crystal form H

The invention provides a novel crystal form, namely a crystal form H, of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid and further provides a preparation method of the crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid. The crystal form H of 3 alpha,7 alpha-dihydroxyl-6 alpha-ethyl-5 beta-cholanic acid, disclosed by the invention contains no crystal solvents or water, has a good crystal form and is good in stability, not easy to absorb moisture, suitable for recrystallization purification and capable of effectively removing impurities.

PROCESS FOR PREPARATION OF OBETICHOLIC ACID

The invention of the present application relates to the process for the preparation of intermediates of obeticholic acid and their conversion to obeticholic acid. The process involves the conversion of compound of formula (VI) to compound of formula (VII) in presence of an organic base.

Method for preparing 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate

The invention belongs to the technical field of medicines, and relates to a method for preparing 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. Preferentially, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate is 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. According to the method, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, especially 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, prepared through the method can be used for preparing obeticholic acid.