915038-24-3

Basic information

• Product Name: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-
• Synonyms: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-;(3alpha,5beta)-6-Ethylidene-3-hydroxy-7-oxocholan-24-oic acid;(4R)-4-((3R,5R,10R,13R)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadeca hydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;Obeticholic acid inpurities;Cholan-24-oic acid, 6-ethylidene-3-hydroxy-7-oxo-, (3α,5β)-
• CAS NO: 915038-24-3
• Molecular Formula: C₂₆H₄₀O₄
• Molecular Weight: 416.5934
• EINECS: -0
• Mol File: 915038-24-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 573.1±43.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-(915038-24-3)
• EPA Substance Registry System: Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-(915038-24-3)

Safety Data

• Hazardous Substances Data: 915038-24-3(Hazardous Substances Data)

Usage

Uses

(3α,?5β)?-6-Eethylidene-?3-?hydroxy-?7-?oxocholan-?24-?oic Acid is an impurity of obeticholic acid.

Upstream product

• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 
• 77341-09-4 methyl 3α-(trimethylsilyloxy)-7-keto-5β-cholan-24-oate 
• 52759-80-5 methyl 3α-7α-ditrimethylsilyloxy-5β-chol-6-en-24-oate 
• 4651-67-6 7-Ketolithocholic acid 
• 10538-59-7 7-ketolithocholic methyl ester 
• 122960-85-4 3α-tetrahydropyranyloxy-7-keto-5β-cholan-24-oic acid 
• 859-97-2 3,7-diketocholanic acid 
• 474-25-9 chenodeoxycholic acid 
• 75-07-0 acetaldehyde 
• 83-46-5 β-sitosterol 
• 863239-58-1 3α,7α-bis((trimethylsilyl)oxy)-6-ene-5β-cholanic acid methyl ester 
• 21066-15-9 methyl 3α-acetoxy-6-oxo-5β-cholanoate 

Downstream Products

• 865244-30-0 (3α,5β,6α,7β)-6-ethyl-3,7-dihydroxycholan-24-oic acid 
• 1537866-42-4 6α-ethyl-3α-formyloxy-7-keto-5β-cholan-24-oic acid 
• 863239-59-2 3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-carboxylic acid methyl ester 

Relevant articles and documents

Preparation method of obeticholic acid

The invention relates to a preparation method of obeticholic acid, in particular to a compound shown as a formula III which is described in the specification, a preparation method of the compound anda method for preparing obeticholic acid through the compound III. The method has the advantages of mild reaction conditions, few byproducts, simplicity and convenience in operation, high total yield and the like, and is suitable for large-scale production.

PROCESS FOR THE PREPARATION OF 3α,7α-DIHYDROXY6α-ETHYL-5β-CHOLAN-24-OIC ACID

The present invention relates to an improved process for the preparation of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid which are useful in the preparation of pure 3α,7α-dihydroxy-6α-ethyl-5β-cholan-24-oic acid.

STEROID DERIVATIVE FXR AGONIST

The present invention relates to a compound represented by formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to applications thereof in the preparation of drugs for treating FXR related diseases.