77356-14-0

Basic information

• Product Name: 2-Propanone, 1,3-bis(phenylMethoxy)-
• Synonyms: 2-Propanone, 1,3-bis(phenylMethoxy)-;1,3-Bis[(phenylmethyl)oxy]-2-propanone;1,3-Dibenzyloxy-2-propanone;1,3-Dibenzyloxyacetone;1,3-BIS(BENZYLOXY)PROPAN-2-ONE;1,3-bis(phenylmethoxy)propan-2-one
• CAS NO: 77356-14-0
• Molecular Formula: C₁₇H₁₈O₃
• Molecular Weight: 270.32302
• Mol File: 77356-14-0.mol
• Article Data: 29

Chemical Properties

• Melting Point: 40℃
• Boiling Point: 208-212 °C(Press: 0.04 Torr)
• Appearance: /
• Density: 1.115±0.06 g/cm3(Predicted)
• Refractive Index: 1.5483 (589.3 nm)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Propanone, 1,3-bis(phenylMethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1,3-bis(phenylMethoxy)-(77356-14-0)
• EPA Substance Registry System: 2-Propanone, 1,3-bis(phenylMethoxy)-(77356-14-0)

Safety Data

• Hazardous Substances Data: 77356-14-0(Hazardous Substances Data)

Usage

General Description

2-Propanone, 1,3-bis(phenylmethoxy)-, also known as dibenzyl ketone, is a chemical compound with the molecular formula C17H16O2. It is a white solid with a slightly sweet, floral odor, and is used as a fragrance ingredient in the production of perfumes and cosmetics. Dibenzyl ketone is also used in the synthesis of pharmaceuticals and as a reagent in organic chemistry reactions. It is considered to be relatively non-toxic and non-irritating to the skin, but prolonged exposure to high concentrations may cause irritation to the respiratory system and eyes. Overall, dibenzyl ketone is a versatile compound with various industrial and commercial applications.

Upstream product

• 6972-79-8 dibenzyl glycerol 
• 534-07-6 1,3-Dichloroacetone 
• 20194-18-7 sodium phenyl-methanolate 
• 27441-79-8 2-methylenepropane-1,3-bisbenzyl ether 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 102956-89-8 1,2,3-tris(benzyloxy)propane 
• 1634-04-4 tert-butyl methyl ether 
• 144-55-8 sodium hydrogencarbonate 
• 106-89-8 epichlorohydrin 

Downstream Products

• 22539-93-1 3-benzyloxypropanone 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 77356-16-2 3-benzyloxymethyl-2-phenyloxetan-3-ol 
• 77356-15-1 cis-7-phenyl-2,4,6-trioxabicyclo<3.2.0>heptan-3-one 
• 77356-15-1 trans-7-phenyl-2,4,6-trioxabicyclo<3.2.0>heptan-3-one 
• 139871-38-8 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxypyrimidine 
• 107053-40-7 ethyl 4-(benzyloxy)-3-<(benzyloxy)methyl>-2-butenoate 
• 86204-05-9 3,5-Bis-benzyloxy-2-hydroxy-2-methyl-4-oxo-pentanoic acid methyl ester 
• 86204-05-9 (2S,3S)-3,5-Bis-benzyloxy-2-hydroxy-2-methyl-4-oxo-pentanoic acid methyl ester 
• 86204-05-9 (2S,3R)-3,5-Bis-benzyloxy-2-hydroxy-2-methyl-4-oxo-pentanoic acid methyl ester 
• 139871-31-1 6-<<2-<1,3-bis(benzyloxy)-2-hydroxypropyl>>methyl>-2,4-dimethoxy-5-methylpyrimidine 
• 142979-78-0 5,5-bis-<(phenylmethoxy)methyl>-2,4-imidazolidinedione 
• 161924-07-8 2-(methoxycarbonyl)oxy-1-benzyloxy-2-benzyloxymethyl-3-butyne 
• 161924-08-9 2-(phenoxycarbonyl)oxy-1-benzyloxy-2-benzyloxymethyl-3-butyne 

Relevant articles and documents

Method for preparing 1,3-dibenzyloxy-2-acetone

The invention discloses a method for preparing 1,3-dibenzyloxy-2-acetone. The method comprises the following steps: carrying out nucleophilic reaction on benzyl alcohol and epoxy chloropropane in an alkaline aqueous solution, washing the nucleophilic reaction mixture with water, carrying out primary extraction by using a first extractant to obtain an organic layer, drying the organic layer for thefirst time, distilling under reduced pressure to remove fractions below 175 DEG C/5 mm Hg to obtain an intermediate product, adding a solvent, phosphorus pentoxide and dimethyl sulfoxide into the intermediate product under the conditions of inert atmosphere and ice-water bath, keeping the inert atmosphere, heating to room temperature, reacting, keeping the inert atmosphere, adding organic amine under the condition of ice-water bath, keeping the inert atmosphere, heating to room temperature, and continuously reacting to generate the 1,3-dibenzyloxy-2-acetone. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, simple operation and high yield.

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition

The synthesis and in vitro properties of six analogues of the selective glucocorticoid receptor (GR) agonist GSK866, bearing a warhead for covalent linkage to the glucocorticoid receptor, is described.

Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: New lead structures for monitoring gene expression in vivo

Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed that our lead compound, N-methyl DHBT (N-methyl-6-(1,3-dihydroxyisobutyl) thymine; N-Me DHBT), is