773846-62-1

Basic information

• Product Name: 2-amino-5-fluoro-N-methylbenzamide
• Synonyms: 2-amino-5-fluoro-N-methylbenzamide;4-Fluoro-2-(methylcarbamoyl)aniline, 4-Fluoro-2-[(methylamino)carbonyl]aniline
• CAS NO: 773846-62-1
• Molecular Formula: C₈H₉FN₂O
• Molecular Weight: 168.1682632
• Mol File: 773846-62-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-5-fluoro-N-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-fluoro-N-methylbenzamide(773846-62-1)
• EPA Substance Registry System: 2-amino-5-fluoro-N-methylbenzamide(773846-62-1)

Safety Data

• Hazardous Substances Data: 773846-62-1(Hazardous Substances Data)

Upstream product

• 878160-05-5 5-fluoro-N-methyl-2-nitrobenzoic acid 
• 321-69-7 5-fluoroisatoic anhydride 
• 74-89-5 methylamine 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 1257994-19-6 diethyl (4-{[4-{[4-fluoro-2-(methylcarbamoyl)phenyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate 

Relevant articles and documents

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is

PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK

The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.

PYRIDINE COMPOUNDS

The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer.