878160-05-5

Basic information

• Product Name: 5-fluoro-N-methyl-2-nitro-benzamide
• Synonyms: Benzamide, 5-fluoro-N-methyl-2-nitro-
• CAS NO: 878160-05-5
• Molecular Formula: C₈H₇FN₂O₃
• Molecular Weight: 198.1511832
• Mol File: 878160-05-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-fluoro-N-methyl-2-nitro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-N-methyl-2-nitro-benzamide(878160-05-5)
• EPA Substance Registry System: 5-fluoro-N-methyl-2-nitro-benzamide(878160-05-5)

Safety Data

• Hazardous Substances Data: 878160-05-5(Hazardous Substances Data)

Upstream product

• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 74-89-5 methylamine 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 878160-06-6 N-methyl-5-(4-methyl-piperazin-1-yl)-2-nitro-benzamide 
• 1061358-13-1 N-methyl-2-nitro-5-(morpholin-4-yl)benzamide 
• 773846-62-1 2-amino-5-fluoro-N-methylbenzamide 
• 1224888-01-0 5-[4-(2-hydroxyethyl)-1-piperazinyl]-N-methyl-2-nitrobenzamide 
• 1290633-91-8 N-methyl-2-nitro-5-(quinuclidin-3-ylamino)benzamide 
• 1025487-75-5 N-methyl-2-amino-5-(morpholin-4-yl)benzamide 

Relevant articles and documents

CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR

The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The present invention further relates to pharmaceutical compositions comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders mediated by nicotinic acetylcholine receptors, such as schizophrenia and Alzheimer's disease.

INHIBITORS OF FOCAL ADHESION KINASE

The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.