77541-65-2

Basic information

• Product Name: 2-BENZYL-5-CHLORO-4-METHOXY-3(2H)-PYRIDAZINONE
• Synonyms: 2-BENZYL-5-CHLORO-4-METHOXY-3(2H)-PYRIDAZINONE;2-Benzyl-5-chloro-4-methoxy-2H-pyridazin-3-one
• CAS NO: 77541-65-2
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.68
• Mol File: 77541-65-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 395.5°C at 760 mmHg
• Flash Point: 193°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.83E-06mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2-BENZYL-5-CHLORO-4-METHOXY-3(2H)-PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-5-CHLORO-4-METHOXY-3(2H)-PYRIDAZINONE(77541-65-2)
• EPA Substance Registry System: 2-BENZYL-5-CHLORO-4-METHOXY-3(2H)-PYRIDAZINONE(77541-65-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 77541-65-2(Hazardous Substances Data)

Usage

General Description

2-BENZYL-5-CHLORO-4-METHOXY-3(2H)-PYRIDAZINONE, also known as BMMP, is a chemical compound with the molecular formula C14H13ClN2O2. It is a pyridazinone derivative with potential antimicrobial and antifungal properties. BMMP has been studied for its potential use in the treatment of various skin infections and has shown promising results in inhibiting the growth of a wide range of bacteria and fungi. Its structure and properties make it a promising compound for further research and development in the field of antimicrobial and antifungal agents.

InChI:InChI=1/C12H11ClN2O2/c1-17-11-10(13)7-14-15(12(11)16)8-9-5-3-2-4-6-9/h2-7H,8H2,1H3

Upstream product

• 124-41-4 sodium methylate 
• 41933-33-9 2-benzyl-4,5-dichloro-3(2H)-pyridazinone 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 476171-97-8 2-(1-benzyl-5-methoxy-6-oxo-1,6-dihydropyridazin-4-yl)benzaldehyde 
• 938045-21-7 2-benzyl-4-methoxy-5-methylpyridazin-3(2H)-one 
• 938045-22-8 2-benzyl-4-hydroxy-5-methylpyridazin-3(2H)-one 
• 938045-33-1 C₁₂H₁₁CF₃SO₂N₂O₂ 
• 938045-23-9 2-benzyl-4-(2-formylphenyl)-5-methylpyridazin-3(2H)-one 
• 938045-24-0 2-benzylbenzo[f]phthalazin-1(2H)-one 
• 476171-99-0 3-benzyl-pyridazino[4,5-c]isoquinolin-4(3H)-one 
• 856250-30-1 2-benzyl-5-(4-chlorophenyl)-4-methoxypyridazin-3(2H)-one 

Relevant articles and documents

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

The design and synthesis of two closely related series of prostacyclin receptor agonist compounds that showed excellent human IP receptor potency and efficacy is described. Compounds from this series showed in vivo activity after SC dosing in the monocrotaline model of PAH in rat.

Macrocyclic hepatitis C serine protease inhibitors

The present invention relates to compounds of Formula I, II or Ill, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction

Suzuki cross-coupling reaction of 2-alkyl(methyl and benzyl)-5-chloro-4-methoxy- and 2-alkyl(methyl and benzyl)-4-chloro-5-methoxypyridazin-3(2H)-ones with 2-formylphenylboronic acid afforded the corresponding biaryl products which were cyclized with ammonia to yield hitherto undescribed pyridazino[4,5-c]isoquinolinones. Removal of the N-benzyl protective group in position 2 yielded the unsubstituted tricyclic pyridazinones.