41933-33-9

Basic information

• Product Name: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE
• Synonyms: OTAVA-BB BB0128630032;2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE;2-BENZYL-4,5-DICHLOROPYRIDAZIN-3(2H)-ONE;2-BENZYL-4,5-DICHLOROPYRIDAZINE-3(2H)-ONE;2-benzyl-4,5-dichloro-2,3-dihydropyridazinone;4,5-dichloro-2-(phenylmethyl)-3(2H)-Pyridazinone
• CAS NO: 41933-33-9
• Molecular Formula: C₁₁H₈Cl₂N₂O
• Molecular Weight: 255.1
• Mol File: 41933-33-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 87℃
• Boiling Point: 338 °C at 760 mmHg
• Flash Point: 158.2 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 0.000101mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE(41933-33-9)
• EPA Substance Registry System: 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE(41933-33-9)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• Hazardous Substances Data: 41933-33-9(Hazardous Substances Data)

Usage

General Description

2-Benzyl-4,5-dichloro-2,3-dihydropyridazin-3-one is a chemical compound with the molecular formula C14H11Cl2N3O. It is a heterocyclic compound that contains a pyridazine ring with two chlorine atoms and a benzyl group attached. 2-BENZYL-4,5-DICHLORO-2,3-DIHYDROPYRIDAZIN-3-ONE has been studied for its potential pharmaceutical properties, including its use as an antipsychotic agent and its effects on the central nervous system. It has also been investigated for its potential as a photosensitizer in photodynamic therapy for cancer. This chemical compound has the potential for various therapeutic applications and continues to be a subject of research in the fields of medicinal and pharmaceutical chemistry.

InChI:InChI=1/C11H8Cl2N2O/c12-9-6-14-15(11(16)10(9)13)7-8-4-2-1-3-5-8/h1-6H,7H2

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 87-56-9 mucochloric acid 
• 1073-62-7 N-benzylhydrazine hydrochloride 

Downstream Products

• 69152-64-3 2-benzyl-4-chloro-5-morpholin-4-yl-2H-pyridazin-3-one 
• 98796-03-3 2-Benzyl-5-chloro-4-pyrrolidin-1-yl-2H-pyridazin-3-one 
• 98796-14-6 2-Benzyl-4-chloro-5-pyrrolidin-1-yl-2H-pyridazin-3-one 
• 41933-15-7 2-benzyl-4-chloro-5-(1-methylhydrazino)-3(2H)-pyridazinone 
• 82412-93-9 2-Benzyl-4-chloro-5-[(2-hydroxy-ethyl)-methyl-amino]-2H-pyridazin-3-one 
• 91364-81-7 5-(2-benzyl-4-benzylamino-2,3-dihydro-3-oxo-pyridazinyl) 5'-(2'-benzyl-4'-chloro-2',3'-dihydro-3'-oxo-pyridazinyl) sulfide 
• 91736-90-2 2-benzyl-4-benzylamino-5-chloro-3(2H)-pyridazinone 
• 96017-19-5 2-Benzyl-4-chloro-5-hydrazino-3(2H)-pyridazinone 
• 40890-47-9 2-benzyl-4-chloro-5-methoxy-2H-pyridazin-3-one 
• 77541-65-2 2-benzyl-5-chloro-4-methoxypyridazin-3(2H)-one 
• 825633-93-0 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one 
• 825634-14-8 2-benzyl-5-[3-hydroxy-3-phenylprop-1-yn-1-yl]pyridazin-3(2H)-one 
• 476171-99-0 3-benzyl-pyridazino[4,5-c]isoquinolin-4(3H)-one 
• 476172-04-0 2-benzyl-pyridazino[4,5-c]isoquinolin-1(2H)-one 

Relevant articles and documents

Design, synthesis, and bioactivities of novel pyridazinone derivatives containing 2-phenylthiazole or oxazole skeletons

A series of novel pyridazinone derivatives were designed and synthesized by replacing 4-(tert-butyl)phenyl moiety of pyridaben with 2-phenylthiazole or oxazole fragments via activity substructure connecting approach. The structures of all target compounds were characterized through NMR, MS, and elemental analysis. Bioassay results exhibit that most compounds showed potent bioactivities against Aphis fabae, Tetranychus urticae, Erysiphe graminis, and/or Puccinia polysora. Among the newly synthesized compounds, 2-(tert-butyl)-4-chloro-5-(((2-phenylthiazol-4-yl)methyl)thio)pyridazin-3(2H)-one (12b) displays remarkable insecticidal activity against A fabae. Its LC50 value (2.73 mg/L) is better than that of pyridaben (5.46 mg/L), although inferior to that of imidacloprid (0.51 mg/L). In addition to its extraordinary insecticidal activity, compound 12b also exerts 96.9% fungicidal activities against P polysora at 500 mg/L in vivo, significantly superior to that of pyridaben (50.0%), while slightly lower than that of tebuconazole (100%). This article discusses the synthesis, bioassay results, and structure-activity relationship of this series of novel pyridazinone derivatives.

One-Pot Highly Regioselective Synthesis of Indole-Fused Pyridazino[4,5- b ][1,4]benzoxazepin-4(3 H)-ones by a Smiles Rearrangement

A simple and convenient synthesis of indole-fused pyridazino[4,5- b ][1,4]benzoxazepin-4(3 H)-ones is described. A range of 2-(1 H -indol-2-yl)phenols and 4,5-dichloropyridazin-3-ones are compatible with this reaction. A Smiles rearrangement is proposed as a key step in the highly regioselective construction of the products. The easy availability of the starting materials makes this an appealing method in organic synthesis.

Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat

The design and synthesis of two closely related series of prostacyclin receptor agonist compounds that showed excellent human IP receptor potency and efficacy is described. Compounds from this series showed in vivo activity after SC dosing in the monocrotaline model of PAH in rat.