825633-93-0

Basic information

• Product Name: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone
• Synonyms: 2-Benzyl-5-iodopyridazin-3(2H)-one;5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone;2-benzyl-5-iodopyridazin-3-one;2-Benzyl-5-iodopyridazin-3(2H)
• CAS NO: 825633-93-0
• Molecular Formula: C₁₁H₉IN₂O
• Molecular Weight: 312
• EINECS: -0
• Mol File: 825633-93-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 136-137℃
• Boiling Point: 370℃
• Flash Point: 178℃
• Appearance: /
• Density: 1.70
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone(825633-93-0)
• EPA Substance Registry System: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone(825633-93-0)

Safety Data

• Hazardous Substances Data: 825633-93-0(Hazardous Substances Data)

Usage

Uses

2-Benzyl-5-iodopyridazin-3(2H)-one is a reactant used in high temperature Pd-catalyzed intramolecular direct arylations.

Upstream product

• 41933-33-9 2-benzyl-4,5-dichloro-3(2H)-pyridazinone 
• 100-39-0 benzyl bromide 
• 825633-94-1 5-iodo-2,3-dihydropyridazin-3-one 

Downstream Products

• 825634-03-5 2-benzyl-5-vinylpyridazin-3(2H)-one 
• 825634-08-0 methyl (2E)-3-(1-benzyl-6-oxo-1,6-dihydropyridazin-4-yl)acrylate 
• 825634-14-8 2-benzyl-5-[3-hydroxy-3-phenylprop-1-yn-1-yl]pyridazin-3(2H)-one 
• 825633-94-1 5-iodo-2,3-dihydropyridazin-3-one 
• 1001620-01-4 C₂₀H₁₆N₂O₃ 
• 1001620-00-3 C₁₆H₁₆N₂O₃ 
• 1041015-02-4 2-benzyl-5-{[2-bromo-4-methylphenyl]amino}pyridazin-3(2H)-one 
• 1041014-98-5 2-benzyl-5-{[2-bromo-4-(trifluoromethoxy)phenyl]amino}pyridazin-3(2H)-one 
• 1235545-41-1 2-benzyl-5-(4-fluorophenyl)pyridazin-3(2H)-one 

Relevant articles and documents

NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

A compound represented by general formula [1] wherein X represents N or the like, Y represents CH or the like; RA represents a cycloalkyl group which may be substituted or the like, R1 represents an alkyl group or the like, R2 represents an alkyl group which may be substituted or the like, R3 represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

SERINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation