776-88-5

Basic information

• Product Name: 5,5-dimethyl-2-phenyl-1,3-dioxane
• Synonyms: 5,5-dimethyl-2-phenyl-1,3-dioxane;2-Phenyl-5,5-dimethyl-1,3-dioxane;Benzaldehyde (2,2-dimethylpropane-1,3-diyl)acetal;Benzaldehyde 2,2-dimethylpropane-1,3-diyl acetal;Benzaldehyde 2,2-dimethyltrimethylene acetal
• CAS NO: 776-88-5
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• EINECS: 212-284-5
• Mol File: 776-88-5.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 269.7°C at 760 mmHg
• Flash Point: 121.7°C
• Appearance: /
• Density: 1.005g/cm³
• Vapor Pressure: 0.0119mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 5,5-dimethyl-2-phenyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-2-phenyl-1,3-dioxane(776-88-5)
• EPA Substance Registry System: 5,5-dimethyl-2-phenyl-1,3-dioxane(776-88-5)

Safety Data

• Hazardous Substances Data: 776-88-5(Hazardous Substances Data)

Usage

General Description

5,5-dimethyl-2-phenyl-1,3-dioxane is a chemical compound with the molecular formula C11H16O2. It is a cyclic ether with a dioxane structure, consisting of a six-membered ring with two oxygen atoms and two alkyl substituents. The compound is a colorless liquid that is used in the production of fragrances and flavors due to its pleasant odor. It is also utilized as a solvent in various industrial processes. Additionally, 5,5-dimethyl-2-phenyl-1,3-dioxane has potential applications in pharmaceuticals and as a precursor for the synthesis of other organic compounds. However, it is important to handle this chemical with caution, as it may pose health risks upon exposure.

InChI:InChI=1/C12H16O2/c1-12(2)8-13-11(14-9-12)10-6-4-3-5-7-10/h3-7,11H,8-9H2,1-2H3

Upstream product

• 100-52-7 benzaldehyde 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 772-01-0 2-phenyl-1,3-dioxane 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 6296-95-3 1,1,2-triphenyl-1,2-ethanediol 
• 579-43-1 (1S,2R)-1,2-diphenylethane-1,2-diol 
• 1439-07-2 trans-Stilbene oxide 
• 100-51-6 benzyl alcohol 
• 62999-86-4 5,5-Dimethyl-2-N,N-dimethylamino-1,3-dioxane 
• 65849-85-6 3,3,9,9-Tetramethyl-1,5,7,11-tetraoxaspiro<5.5>undecan 
• 583-60-8 2-Methylcyclohexanone 
• 774-48-1 (diethoxymethyl)benzene 
• 103-82-2 phenylacetic acid 
• 599-67-7 1,1-diphenylethanol 

Downstream Products

• 38216-93-2 3-benzyloxypivalic aldehyde 
• 772-01-0 2-phenyl-1,3-dioxane 
• 66582-32-9 3-(benzyloxy)-2,2-dimethylpropan-1-ol 
• 70659-74-4 3-bromo-2,2-dimethylpropyl benzoate 
• 10503-36-3 exo-7-phenyl-norcarane 
• 10503-37-4 7-phenylbicyclo[4.1.0]heptane 
• 100-52-7 benzaldehyde 
• 36881-14-8 3-(benzyloxy)-2,2-dimethylpropionic acid 
• 65-85-0 benzoic acid 
• 5522-92-9 2,2-dimethyl-1,3-propanediol 1-benzoate 
• 957791-54-7 (E)-N-(3-(benzyloxy)-2,2-dimethylpropylidene)-4-methoxybenzenamine 
• 957791-46-7 (3R,4S)-3-acetoxy-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidin-2-one 
• 865154-57-0 (3S,4R)-4-(2-benzyloxy-1,1-dimethylethyl)-3-hydroxy-1-(4-methoxyphenyl)azetidin-2-one 
• 865154-54-7 (3R,4S)-3-hydroxy-4-(2-benzyloxy-1,1-dimethylethyl)-1-(4-methoxyphenyl)azetidin-2-one 

Relevant articles and documents

Evaluation of the Pharmacophoric Role of the O-O Bond in Synthetic Antileishmanial Compounds: Comparison between 1,2-Dioxanes and Tetrahydropyrans

Leishmaniases are neglected diseases that can be treated with a limited drug arsenal; the development of new molecules is therefore a priority. Recent evidence indicates that endoperoxides, including artemisinin and its derivatives, possess antileishmanial activity. Here, 1,2-dioxanes were synthesized with their corresponding tetrahydropyrans lacking the peroxide bridge, to ascertain if this group is a key pharmacophoric requirement for the antileishmanial bioactivity. Newly synthesized compounds were examined in vitro, and their mechanism of action was preliminarily investigated. Three endoperoxides and their corresponding tetrahydropyrans effectively inhibited the growth of Leishmania donovani promastigotes and amastigotes, and iron did not play a significant role in their activation. Further, reactive oxygen species were produced in both endoperoxide-and tetrahydropyran-Treated promastigotes. In conclusion, the peroxide group proved not to be crucial for the antileishmanial bioactivity of endoperoxides, under the tested conditions. Our findings reveal the potential of both 1,2-dioxanes and tetrahydropyrans as lead compounds for novel therapies against Leishmania.

Phosphorus promoted SO42-/TiO2 solid acid catalyst for acetalization reaction

A novel phosphorus modifed SO42-/TiO2 catalyst was synthesized by a facile coprecipitation method, followed by calcination. The catalytic performance of this novel solid acid was evaluated by acetalization. The results showed that the phosphorus was very effcient to enhance the catalytic activity of SO42-/TiO2. The solid acid owned high activity for the acetalization with the yields over 90%. Moreover, the solid acid could be reused for six times without loss of initial catalytic activities.

Rapid assessment of protecting-group stability by using a robustness screen

An experimentally simple method has been developed to rapidly establish the stability of widely utilized silyl, acetal, and carbamate protecting groups to a given set of reaction conditions. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Evaluation of this protocol in two unrelated synthetic transformations suggests that this method can be used to select appropriate protecting groups in the design of synthetic routes.