7764-30-9Relevant articles and documents
Symmetrical diaza disulfide compound as well as synthesis method and application thereof
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Paragraph 0087-0090, (2021/10/27)
The invention discloses a formula (1). The method comprises the following steps: reacting the compound represented by the formula (2), the formula (3) and the formula (4 6 5) with dichloro disulfide as a reaction raw material, and reacting under the action of a base to obtain the symmetrical disulfide compound. The method has the advantages of mild reaction conditions, cheap and accessible raw materials, simple reaction operation and high yield. The reaction substrate is easy to prepare. The reaction is an amplification reaction. The reaction of the present invention can be used to construct novel polysulfide compounds.
BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY
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Page/Page column 7; 19, (2019/10/01)
The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.
An internal oxidant-directing strategy enabling transition metal-free C–S bond ligation
Zuo, Yingying,Xiong, Feng,Zhao, Jing
supporting information, p. 4174 - 4179 (2019/05/24)
Organic sulfur compounds have broad applications in biology, medicine and material sciences and intensive efforts have been devoted to developing mild and general C–S bond-forming methods. However, a mild, transition-metal-free, direct C–H bond functionalization method remains elusive. Here, we report the use of an internal oxidant-directing strategy to achieve this goal. The cascade reactions described here show excellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation reagents. This study enlarges the synthesis toolbox for preparing structurally diverse sulfilimines under mild conditions.